PMID- 35096939
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230917
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 8
DP  - 2021
TI  - Effects of Resistant Starch Interventions on Metabolic Biomarkers in Pre-Diabetes 
      and Diabetes Adults.
PG  - 793414
LID - 10.3389/fnut.2021.793414 [doi]
LID - 793414
AB  - Simple lifestyle changes can prevent or delay the onset of type 2 diabetes 
      mellitus (T2DM). In addition to maintaining a physically active way of life, the 
      diet has become one of the bases in managing TD2M. Due to many studies linking 
      the ability of resistant starch (RS) to a substantial role in enhancing the 
      nutritional quality of food and disease prevention, the challenge of 
      incorporating RS into the diet and increasing its intake remains. Therefore, we 
      conducted this review to assess the potential benefits of RS on metabolic 
      biomarkers in pre-diabetes and diabetes adults based on available intervention 
      studies over the last decade. Based on the conducted review, we observed that RS 
      intake correlates directly to minimize possible effects through different 
      mechanisms for better control of pre-diabetic and diabetic conditions. In most 
      studies, significant changes were evident in the postprandial glucose and insulin 
      incremental area under the curve (iAUC). Comparative evaluation of RS consumption 
      and control groups also showed differences with inflammatory markers such as 
      TNF-alpha, IL-1beta, MCP-1, and E-selectin. Only RS2 and RS3 were extensively 
      investigated and widely reported among the five reported RS types. However, a 
      proper comparison and conclusion are deemed inappropriate considering the 
      variations observed with the study duration, sample size, subjects and their 
      metabolic conditions, intervention doses, and the intervention base products. In 
      conclusion, this result provides interesting insights into the potential use of 
      RS as part of a sustainable diet in diabetes management and should be further 
      explored in terms of the mechanism involved.
CI  - Copyright (c) 2022 Rashed, Saparuddin, Rathi, Nasir and Lokman.
FAU - Rashed, Aswir Abd
AU  - Rashed AA
AD  - Nutrition Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), 
      Institute for Medical Research, National Institutes of Health, Ministry of Health 
      Malaysia, Setia Alam, Malaysia.
FAU - Saparuddin, Fatin
AU  - Saparuddin F
AD  - Endocrine and Metabolic Unit, Nutrition, Metabolism and Cardiovascular Research 
      Centre (NMCRC), Institute for Medical Research, National Institutes of Health, 
      Ministry of Health Malaysia, Setia Alam, Malaysia.
FAU - Rathi, Devi-Nair Gunasegavan
AU  - Rathi DG
AD  - Nutrition Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), 
      Institute for Medical Research, National Institutes of Health, Ministry of Health 
      Malaysia, Setia Alam, Malaysia.
FAU - Nasir, Nur Najihah Mohd
AU  - Nasir NNM
AD  - Nutrition Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), 
      Institute for Medical Research, National Institutes of Health, Ministry of Health 
      Malaysia, Setia Alam, Malaysia.
FAU - Lokman, Ezarul Faradianna
AU  - Lokman EF
AD  - Endocrine and Metabolic Unit, Nutrition, Metabolism and Cardiovascular Research 
      Centre (NMCRC), Institute for Medical Research, National Institutes of Health, 
      Ministry of Health Malaysia, Setia Alam, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220112
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC8790517
OTO - NOTNLM
OT  - biomarkers
OT  - glucose
OT  - insulin
OT  - resistant starch
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/01 06:00
MHDA- 2022/02/01 06:01
PMCR- 2021/01/01
CRDT- 2022/01/31 06:00
PHST- 2021/10/12 00:00 [received]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2022/01/31 06:00 [entrez]
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/02/01 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2021.793414 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jan 12;8:793414. doi: 10.3389/fnut.2021.793414. eCollection 
      2021.