PMID- 35096950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230917
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 8
DP  - 2021
TI  - Simultaneous Quantification of Chloramphenicol, Thiamphenicol, Florfenicol, and 
      Florfenicol Amine in Animal and Aquaculture Products Using Liquid 
      Chromatography-Tandem Mass Spectrometry.
PG  - 812803
LID - 10.3389/fnut.2021.812803 [doi]
LID - 812803
AB  - The accumulation of antimicrobial residues in edible animal products and 
      aquaculture products could pose health concerns to unsuspecting consumers. Hence, 
      this study aimed to develop a validated method for simultaneous quantification of 
      chloramphenicol (CAP), thiamphenicol (TAP), florfenicol (FF), and florfenicol 
      amine (FFA) in beef, pork, chicken, shrimp, eel, and flatfish using a quick, 
      easy, cheap, effective, rugged, and safe (QuEChERS) extraction method coupled 
      with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Primary-secondary 
      amine (PSA) and MgSO(4) were used for sample purification. The analytes were 
      separated on a reversed-phase analytical column. The coefficients of 
      determination for the linear matrix-matched calibration curves were >/=0.9941. 
      Recovery rates ranged between 64.26 and 116.51% for the four analytes with 
      relative standard deviations (RSDs) </= 18.05%. The calculated limits of detection 
      (LODs) and limits of quantification (LOQs) were 0.005-3.1 and 0.02-10.4 mug/kg, 
      respectively. The developed method was successfully applied for monitoring 
      samples obtained from local markets in Seoul, Republic of Korea. The target 
      residues were not detected in any tested matrix. The designed method was 
      versatile, sensitive, and proved suitable for quantifying residues in 
      animal-derived products.
CI  - Copyright (c) 2022 Jung, Park, Choi, Kang, Cho, Choi, Shim, Zaky, Abd El-Aty and 
      Shin.
FAU - Jung, Hae-Ni
AU  - Jung HN
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Park, Da-Hee
AU  - Park DH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Choi, Yeon-Jae
AU  - Choi YJ
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Kang, Se-Hyeong
AU  - Kang SH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Cho, Hee-Jung
AU  - Cho HJ
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Choi, Jeong-Min
AU  - Choi JM
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
FAU - Shim, Jae-Han
AU  - Shim JH
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, Gwangju, South Korea.
FAU - Zaky, Ahmed A
AU  - Zaky AA
AD  - Department of Food Technology, National Research Centre, Cairo, Egypt.
FAU - Abd El-Aty, A M
AU  - Abd El-Aty AM
AD  - Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 
      Giza, Egypt.
AD  - Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 
      Turkey.
FAU - Shin, Ho-Chul
AU  - Shin HC
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20220113
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC8793773
OTO - NOTNLM
OT  - LC-MS/MS
OT  - chloramphenicol
OT  - florfenicol
OT  - florfenicol amine
OT  - method development
OT  - residue analysis
OT  - thiamphenicol
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/01 06:00
MHDA- 2022/02/01 06:01
PMCR- 2021/01/01
CRDT- 2022/01/31 06:00
PHST- 2021/11/10 00:00 [received]
PHST- 2021/12/06 00:00 [accepted]
PHST- 2022/01/31 06:00 [entrez]
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/02/01 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2021.812803 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jan 13;8:812803. doi: 10.3389/fnut.2021.812803. eCollection 
      2021.