PMID- 35097333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2473-0114 (Electronic)
IS  - 2473-0114 (Linking)
VI  - 4
IP  - 3
DP  - 2019 Jul
TI  - Intense Therapeutic Ultrasound for Pain Relief in the Treatment for Chronic 
      Plantar Fasciopathy.
PG  - 2473011419862228
LID - 10.1177/2473011419862228 [doi]
LID - 2473011419862228
AB  - BACKGROUND: Intense therapeutic ultrasound (ITU) is an innovative 
      ultrasound-based therapy where sound waves are concentrated into select 
      musculoskeletal tissue. These focused waves generate thermal coagula at a 
      controlled depth and space while preserving surrounding tissues. A multicenter 
      study was conducted evaluating the efficiency, safety, and patient tolerance of 
      ITU for the treatment of chronic plantar fasciitis (CPF) pain. METHODS: 
      Seventy-four CPF patients, having failed conservative and/or minimally invasive 
      treatment, participated in the study. Randomized participants either received 2 
      ITU treatments or 2 sham ITU treatments in addition to standard-of-care therapy. 
      Plantar fascia pain was assessed pretreatment and at 4, 8, 12, and 26 weeks after 
      treatment. Diagnostic ultrasonographic images were analyzed to examine 
      hypoechoic, perifascial lesions whose volumes were calculated until week 12. 
      Function and patient satisfaction were measured using self-reported outcome 
      measures. RESULTS: The treated group reported significant average pain reduction 
      (-26%, -33%, -43%) and hypoechoic lesion volume (-33%, -53%, -68%) at weeks 4, 8, 
      and 12 compared to baseline. Although the control/sham group reported 
      insignificant pain changes at the same time points (-5%, +8%, and +2%) and 
      increased hypoechoic lesion volume (+15%, +28%, +58%). Treated patients reported 
      a significant increase in daily living activities (+28%, +42%, +47%, +40%) 
      compared to the sham/control group (+0.12%, +12%, +3%, +21%). Patient 
      satisfaction remained more than 80% at weeks 8, 12, and 26 for all treatment 
      groups. CONCLUSION: ITU is an effective pain relief treatment for CPF, which is 
      refractory to either conservative measures or minimally invasive treatments. 
      LEVEL OF EVIDENCE: Level II.
CI  - (c) The Author(s) 2019.
FAU - Slayton, Michael H
AU  - Slayton MH
AD  - Guided Therapy Systems, Inc, Mesa, AZ, USA.
FAU - Baravarian, Bob
AU  - Baravarian B
AD  - University Foot & Ankle Institute, Santa Monica, CA, USA.
FAU - Amodei, Richard C
AU  - Amodei RC
AUID- ORCID: 0000-0003-0630-4374
AD  - Guided Therapy Systems, Inc, Mesa, AZ, USA.
FAU - Compton, Keegan B
AU  - Compton KB
AD  - Guided Therapy Systems, Inc, Mesa, AZ, USA.
FAU - Christensen, Dallin Neil
AU  - Christensen DN
AD  - College of Medicine, University of Arizona, Tucson, AZ, USA.
FAU - McNelly, Ashley
AU  - McNelly A
AD  - College of Medicine, University of Arizona, Tucson, AZ, USA.
FAU - Latt, L Daniel
AU  - Latt LD
AUID- ORCID: 0000-0002-9925-3440
AD  - College of Medicine, University of Arizona, Tucson, AZ, USA.
LA  - eng
PT  - Journal Article
DEP - 20190820
PL  - United States
TA  - Foot Ankle Orthop
JT  - Foot & ankle orthopaedics
JID - 101752333
PMC - PMC8696915
OTO - NOTNLM
OT  - FAAM
OT  - hypoechoic lesion
OT  - intense therapeutic ultrasound (ITU)
OT  - musculoskeletal pain relief
OT  - plantar fascia therapy
OT  - plantar fasciitis
OT  - plantar fasciopathy
COIS- Declaration of Conflicting Interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: Michael H. Slayton, PhD, reports a patent European 
      Patent #2081646- Method and System for Treating Muscle, Tissue, Tendon, Ligament 
      and Cartilage Tissue issued, a patent US Application #13/136,541-Methods and 
      Systems for treating plantar fascia pending, a patent US Application #15/978,651- 
      Systems and Methods for Treating Acute and/or Chronic Injuries in Soft Tissue 
      pending, and a patent European publication #EP20600937- Systems and Methods for 
      Treating Acute and/or Chronic Injuries in Soft Tissue pending. Bob Baravarian, 
      DPM, and L. Daniel Latt, MD, PhD, report grants from Guided Therapy Systems, 
      Inc., during the conduct of the study. Michael H. Slayton, PhD, Richard C. 
      Amodei, RDMS, and Keegan B. Compton, MS, are affiliated with Guided Therapy 
      Systems. ICMJE forms for all authors are available online.
EDAT- 2019/08/20 00:00
MHDA- 2019/08/20 00:01
PMCR- 2019/08/20
CRDT- 2022/01/31 06:02
PHST- 2022/01/31 06:02 [entrez]
PHST- 2019/08/20 00:00 [pubmed]
PHST- 2019/08/20 00:01 [medline]
PHST- 2019/08/20 00:00 [pmc-release]
AID - 10.1177_2473011419862228 [pii]
AID - 10.1177/2473011419862228 [doi]
PST - epublish
SO  - Foot Ankle Orthop. 2019 Aug 20;4(3):2473011419862228. doi: 
      10.1177/2473011419862228. eCollection 2019 Jul.