PMID- 35098094
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2587-0394 (Electronic)
IS  - 2459-1777 (Print)
IS  - 2459-1777 (Linking)
VI  - 5
IP  - 3
DP  - 2020
TI  - Evaluation of Posterior Ocular Structures in Patients with Isolated Iris 
      Coloboma.
PG  - 228-233
LID - 10.14744/bej.2020.72621 [doi]
AB  - OBJECTIVES: To measure lamina cribrosa thickness (LCT), lamina cribrosa depth 
      (LCD) and subfoveal choroidal thickness (SFCT) by imaging posterior ocular 
      structures in pediatric cases with isolated unilateral iris coloboma and to 
      investigate the differences as compared with healthy contralateral eyes of these 
      cases (fellow eyes) and healthy control eyes. METHODS: This cross-sectional, 
      comparative prospective study included seven children (age range, 9-17 years) 
      with unilateral isolated iris coloboma. The healthy contralateral eyes of these 
      cases formed the fellow group. An age-matched (age range 8-17 years) control 
      group (n=9), including children with both eyes having either normal or 
      corrected-to-normal visual acuity, was formed. A detailed ophthalmic examination 
      was performed. The posterior ocular segments were evaluated using spectral 
      domain-optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) 
      technique. RESULTS: The SFCT was 372.0+/-48.8 microm, 375.3+/-44.0 microm, and 386.5+/-71.8 microm, 
      respectively, and the LCD was 362.4+/-68.3 microm, 354.4+/-47.1 microm, and 350.7+/-38.1 microm, 
      respectively, in the coloboma, fellow, and control eyes. There was no difference 
      between the groups regarding SFCT and LCD. The mean LCT was significantly thinner 
      in the coloboma eyes (200.2+/-9.5 microm) than in the fellow (238.8+/-26.7 microm; p=0.023) 
      and control eyes (240.0+/-12.9 microm; p<0.001). The LCT showed no significant 
      correlation with age, axial length or spherical equivalent. CONCLUSION: Better 
      visual prognosis is expected in isolated iris coloboma. However, detailed 
      examinations using new technologies, such as SD-OCT, may reveal some structural 
      changes. Longitudinal studies are required to understand if a thinner LCT in 
      coloboma eyes is associated with any future problems.
CI  - Copyright: (c) 2020 by Beyoglu Eye Training and Research Hospital.
FAU - Akkaya, Serkan
AU  - Akkaya S
AD  - Department of Ophthalmology, Kayseri Training and Research Hospital, Kayseri, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201016
PL  - Turkey
TA  - Beyoglu Eye J
JT  - Beyoglu eye journal
JID - 101777848
PMC - PMC8784471
OTO - NOTNLM
OT  - Coloboma of iris
OT  - choroid
OT  - lamina cribrosa
OT  - optical coherence tomography
COIS- Conflict of Interest: None declared.
EDAT- 2020/10/16 00:00
MHDA- 2020/10/16 00:01
PMCR- 2020/10/16
CRDT- 2022/01/31 06:04
PHST- 2020/07/27 00:00 [received]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2022/01/31 06:04 [entrez]
PHST- 2020/10/16 00:00 [pubmed]
PHST- 2020/10/16 00:01 [medline]
PHST- 2020/10/16 00:00 [pmc-release]
AID - BEJ-5-228 [pii]
AID - 10.14744/bej.2020.72621 [doi]
PST - epublish
SO  - Beyoglu Eye J. 2020 Oct 16;5(3):228-233. doi: 10.14744/bej.2020.72621. 
      eCollection 2020.