PMID- 35098997
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220502
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 60
IP  - 3
DP  - 2022 Mar 3
TI  - Serum total IgE may be a biomarker among chronic pulmonary aspergillosis patients 
      with elevated serum total IgE levels: A cohort study with pathological 
      evaluations.
LID - myac006 [pii]
LID - 10.1093/mmy/myac006 [doi]
AB  - High serum total immunoglobulin E (IgE) levels have been reported in chronic 
      pulmonary aspergillosis (CPA). However, researchers have not verified if they 
      reflect the disease activity. We aimed to compare the serum total IgE levels in 
      CPA cases with high serum IgE during an exacerbation or when stable and examined 
      the IgE expression patterns in the lesions via immunofluorescence staining. From 
      April 2016 to September 2019, we extracted CPA cases with elevated serum total 
      IgE levels based on the criteria of the Infectious Diseases Society of America. 
      We retrospectively analyzed serum total IgE levels and other parameters and 
      eventually extracted 32 cases. The patients' serum total IgE levels were 
      significantly higher in the exacerbation period than in the stable period 
      (P < .0001). The median rate of change was 1.76 times (quartile 1.41-3.25). In 
      addition, we used surgical specimens of CPA cases with high serum total IgE 
      levels, normal serum total IgE CPA cases, and control surgical specimens and 
      performed immunofluorescence staining with IgE, mast cell tryptase, CD138, and 
      4,6-diamidino-2-phenylindole. We observed multiple mast cells and plasma cells in 
      the CPA cases regardless of the serum total IgE level. In contrast, multiple 
      IgE-positive cells co-stained with tryptase were observed in CPA cases with high 
      serum total IgE levels. This finding suggested that serum total IgE could serve 
      as a biomarker for evaluating disease severity. Immunofluorescence staining 
      suggested that IgE may play a role in pathogenesis through activation of mast 
      cells by cross-linking in cases of CPA with high serum total IgE levels. LAY 
      SUMMARY: High serum total IgE levels are common in chronic pulmonary 
      aspergillosis. This novel study indicated that serum total IgE is a possible 
      biomarker of the disease activity in the aforementioned condition. 
      Immunofluorescence staining indicated a possible role of IgE in disease 
      pathogenesis.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology.
FAU - Watanabe, Shizuka
AU  - Watanabe S
AUID- ORCID: 0000-0003-3012-826X
AD  - Clinical Research Center, National Hospital Organization Tokyo National Hospital, 
      Kiyose-shi, Tokyo, 204-8585, Japan.
AD  - Department of Respiratory Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 
      113-8655, Japan.
FAU - Suzuki, Junko
AU  - Suzuki J
AD  - Center for Pulmonary Diseases, National Hospital Organization Tokyo National 
      Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Suzukawa, Maho
AU  - Suzukawa M
AD  - Clinical Research Center, National Hospital Organization Tokyo National Hospital, 
      Kiyose-shi, Tokyo, 204-8585, Japan.
AD  - Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo 
      National Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Takeda, Keita
AU  - Takeda K
AD  - Center for Pulmonary Diseases, National Hospital Organization Tokyo National 
      Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Imoto, Sahoko
AU  - Imoto S
AD  - Clinical Research Center, National Hospital Organization Tokyo National Hospital, 
      Kiyose-shi, Tokyo, 204-8585, Japan.
AD  - Department of Respiratory Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 
      113-8655, Japan.
FAU - Kitani, Masashi
AU  - Kitani M
AD  - Department of Pathology, National Hospital Organization Tokyo National Hospital, 
      Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Fukami, Takeshi
AU  - Fukami T
AD  - Department of Thoracic Surgery, National Hospital Organization Tokyo National 
      Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Sasaki, Yuka
AU  - Sasaki Y
AD  - Center for Pulmonary Diseases, National Hospital Organization Tokyo National 
      Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Hebisawa, Akira
AU  - Hebisawa A
AD  - Department of Pathology, National Hospital Organization Tokyo National Hospital, 
      Kiyose-shi, Tokyo, 204-8585, Japan.
FAU - Matsui, Hirotoshi
AU  - Matsui H
AD  - Center for Pulmonary Diseases, National Hospital Organization Tokyo National 
      Hospital, Kiyose-shi, Tokyo, 204-8585, Japan.
LA  - eng
GR  - 21ek0410055/Japan Agency for Medical Research and Development/
PT  - Journal Article
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Immunoglobulin E
MH  - *Pulmonary Aspergillosis/veterinary
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Chronic pulmonary aspergillosis
OT  - biomarker
OT  - immunofluorescence staining
OT  - pulmonology
OT  - serum total IgE
EDAT- 2022/02/01 06:00
MHDA- 2022/03/08 06:00
CRDT- 2022/01/31 08:43
PHST- 2021/08/27 00:00 [received]
PHST- 2022/01/02 00:00 [revised]
PHST- 2022/01/28 00:00 [accepted]
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2022/01/31 08:43 [entrez]
AID - 6517702 [pii]
AID - 10.1093/mmy/myac006 [doi]
PST - ppublish
SO  - Med Mycol. 2022 Mar 3;60(3):myac006. doi: 10.1093/mmy/myac006.