PMID- 35100003
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20230508
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 95
IP  - 1132
DP  - 2022 Apr 1
TI  - Standalone portable xenon-129 hyperpolariser for multicentre clinical magnetic 
      resonance imaging of the lungs.
PG  - 20210872
LID - 10.1259/bjr.20210872 [doi]
LID - 20210872
AB  - OBJECTIVES: Design and build a portable xenon-129 ((129)Xe) hyperpolariser for 
      clinically accessible (129)Xe lung MRI. METHODS: The polariser system consists of 
      six main functional components: (i) a laser diode array and optics; (ii) a B(0) 
      coil assembly; (iii) an oven containing an optical cell; (iv) NMR and optical 
      spectrometers; (v) a gas-handling manifold; and (vi) a cryostat within a 
      permanent magnet. All components run without external utilities such as 
      compressed air or three-phase electricity, and require just three mains sockets 
      for operation. The system can be manually transported in a lightweight van and 
      rapidly installed on a small estates footprint in a hospital setting. RESULTS: 
      The polariser routinely provides polarised (129)Xe for routine clinical lung MRI. 
      To test the concept of portability and rapid deployment, it was transported 200 
      km, installed at a hospital with no previous experience with the technology and 
      (129)Xe MR images of a diagnostic quality were acquired the day after system 
      transport and installation. CONCLUSION: This portable (129)Xe hyperpolariser 
      system could form the basis of a cost-effective platform for wider clinical 
      dissemination and multicentre evaluation of (129)Xe lung MR imaging. ADVANCES IN 
      KNOWLEDGE: Our work successfully demonstrates the feasibility of multicentre 
      clinical (129)Xe MRI with a portable hyperpolariser system.
FAU - Norquay, Graham
AU  - Norquay G
AUID- ORCID: 0000-0002-4108-9035
AD  - POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University 
      of Sheffield, Sheffield, UK.
FAU - Collier, Guilhem J
AU  - Collier GJ
AD  - POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University 
      of Sheffield, Sheffield, UK.
FAU - Rodgers, Oliver I
AU  - Rodgers OI
AD  - POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University 
      of Sheffield, Sheffield, UK.
FAU - Gill, Andrew B
AU  - Gill AB
AD  - Department of Radiology, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
FAU - Screaton, Nicholas J
AU  - Screaton NJ
AD  - Department of Radiology, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
FAU - Wild, Jim
AU  - Wild J
AD  - POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University 
      of Sheffield, Sheffield, UK.
LA  - eng
GR  - MR/M008894/1/MRC_/Medical Research Council/United Kingdom
GR  - SP/14/6/31350/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
DEP - 20220131
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
RN  - 0 (Xenon Isotopes)
RN  - 0 (Xenon-129)
SB  - IM
MH  - Humans
MH  - Lung/diagnostic imaging
MH  - *Magnetic Resonance Imaging/methods
MH  - Magnetic Resonance Spectroscopy
MH  - *Xenon Isotopes
PMC - PMC9153725
EDAT- 2022/02/01 06:00
MHDA- 2022/03/24 06:00
PMCR- 2022/01/31
CRDT- 2022/01/31 17:13
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2022/01/31 17:13 [entrez]
PHST- 2022/01/31 00:00 [pmc-release]
AID - 10.1259/bjr.20210872 [doi]
PST - ppublish
SO  - Br J Radiol. 2022 Apr 1;95(1132):20210872. doi: 10.1259/bjr.20210872. Epub 2022 
      Jan 31.