PMID- 35100480
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220506
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 50
IP  - 6
DP  - 2022 Jun
TI  - A rare case of intracytoplasmic mucin-rich nasopharyngeal carcinoma.
PG  - E151-E155
LID - 10.1002/dc.24934 [doi]
AB  - Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated tumor 
      with a high incidence in Asian countries. NPC is a type of squamous cell 
      carcinoma originating from the nasopharyngeal mucosa. Although rare, NPCs show 
      some uncommon histologic variants; these variations remain to be understood. We 
      described the cytologic characteristics of a rare NPC variant with abundant 
      intracytoplasmic mucin. A 37-year-old Japanese man presented to our hospital with 
      bilateral ear discomfort and palpable lymph nodes. Nasopharyngeal biopsy showed 
      tumor cells with abundant intracytoplasmic, Alcian blue-PAS-positive mucin. 
      Immunohistochemical analysis demonstrated that the tumor cells were positive for 
      p40 and p53. Epstein-Barr encoding region (EBER) in situ hybridization (ISH) 
      showed EBV infection of the tumor cells. Fluorescence in situ hybridization 
      (FISH) using MAML2 break-apart probes did not show split signals. Fine needle 
      aspiration biopsy (FNAB) cytology of the metastatic lymph nodes was also 
      performed. Smear samples had a necrotic and inflammatory background with both 
      lymphocyte and neutrophil infiltration. Highly cellular tumor clusters and 
      dispersed cells with naked nuclei were observed. The tumor cells showed a clear 
      cytoplasm with distinct cell borders. Intracytoplasmic mucin pushing the nucleus 
      to the periphery was observed in the scattered tumor cells in a liquid-based 
      cytology sample. Given these findings, the final diagnosis was advanced 
      nasopharyngeal carcinoma; cisplatin-based chemoradiation therapy was performed as 
      the first-line treatment. The tumor recurred 8 months after completing the 
      treatment. The recurrent nasopharyngeal tumor was a typical non-keratinizing NPC 
      and lacked intracytoplasmic mucin.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Yamaguchi, Yohei
AU  - Yamaguchi Y
AUID- ORCID: 0000-0002-1060-9018
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
FAU - Odate, Toru
AU  - Odate T
AUID- ORCID: 0000-0001-6273-2192
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
FAU - Nakazawa, Kumiko
AU  - Nakazawa K
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
FAU - Oishi, Naoki
AU  - Oishi N
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
FAU - Mochizuki, Kunio
AU  - Mochizuki K
AUID- ORCID: 0000-0001-9577-0320
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
FAU - Shimizu, Tatsuya
AU  - Shimizu T
AD  - Department of Radiology, University of Yamanashi, Yamanashi, Japan.
FAU - Horiuchi, Kiwako
AU  - Horiuchi K
AD  - Department of Otolaryngology, Head and Neck Surgery, Interdisciplinary Graduate 
      School of Medicine, University of Yamanashi, Yamanashi, Japan.
FAU - Ishii, Hiroki
AU  - Ishii H
AD  - Department of Otolaryngology, Head and Neck Surgery, Interdisciplinary Graduate 
      School of Medicine, University of Yamanashi, Yamanashi, Japan.
FAU - Sakurai, Daiju
AU  - Sakurai D
AD  - Department of Otolaryngology, Head and Neck Surgery, Interdisciplinary Graduate 
      School of Medicine, University of Yamanashi, Yamanashi, Japan.
FAU - Kondo, Tetsuo
AU  - Kondo T
AD  - Department of Pathology, University of Yamanashi, Yamanashi, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220131
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Mucins)
SB  - IM
MH  - *Epstein-Barr Virus Infections/diagnosis
MH  - Herpesvirus 4, Human/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mucins
MH  - Nasopharyngeal Carcinoma/diagnosis
MH  - *Nasopharyngeal Neoplasms/diagnosis
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - cytology
OT  - lymph node
OT  - mucin
OT  - nasopharyngeal carcinoma
EDAT- 2022/02/01 06:00
MHDA- 2022/05/07 06:00
CRDT- 2022/01/31 17:16
PHST- 2022/01/18 00:00 [revised]
PHST- 2021/12/06 00:00 [received]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
PHST- 2022/01/31 17:16 [entrez]
AID - 10.1002/dc.24934 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2022 Jun;50(6):E151-E155. doi: 10.1002/dc.24934. Epub 2022 Jan 
      31.