PMID- 35101595
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220620
IS  - 1943-7811 (Electronic)
IS  - 1525-1578 (Linking)
VI  - 24
IP  - 5
DP  - 2022 May
TI  - A Model for Design and Implementation of a Laboratory Information-Management 
      System Specific for Molecular Pathology Laboratory Operations.
PG  - 503-514
LID - S1525-1578(22)00012-5 [pii]
LID - 10.1016/j.jmoldx.2022.01.002 [doi]
AB  - The Molecular Pathology Section, Cleveland Clinic (Cleveland, OH), has undergone 
      enhancement of its testing portfolio and processes. An Excel 2013- and 
      paper-based data-management system was replaced with a commercially available 
      laboratory information-management system (LIMS) software application, a separate 
      bioinformatics platform, customized test-interpretation applications, a dedicated 
      sample-accessioning service, and a results-releasing software application. The 
      customized LIMS solution manages complex workflows, large-scale data packets, and 
      process automation. A customized approach was required because, in a survey of 
      commercially available off-the-shelf software products, none met the diverse and 
      complex needs of this molecular diagnostics service. The project utilized the 
      expertise of clinical laboratorians, pathologists, genetics counselors, 
      bioinformaticians, and systems analysts in partnering with software-engineering 
      consultants to design and implement a solution. Concurrently, Agile 
      software-building best practices were formulated, which may be emulated for 
      scalable and cost-effective laboratory-authored software.
CI  - Copyright (c) 2022 Association for Molecular Pathology and American Society for 
      Investigative Pathology. Published by Elsevier Inc. All rights reserved.
FAU - Tomlinson, Eban
AU  - Tomlinson E
AD  - Semaphore Solutions, Victoria, British Columbia, Canada.
FAU - Goodman, Jennifer
AU  - Goodman J
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Loftus, Margaret
AU  - Loftus M
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Bitto, Stephen
AU  - Bitto S
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Carpenter, Erica
AU  - Carpenter E
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Oddo, Richard
AU  - Oddo R
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Judis, LuAnn
AU  - Judis L
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Ali, Shabab
AU  - Ali S
AD  - Semaphore Solutions, Victoria, British Columbia, Canada.
FAU - Robinson, Wyatt E
AU  - Robinson WE
AD  - Semaphore Solutions, Victoria, British Columbia, Canada.
FAU - Carver, Miranda
AU  - Carver M
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Ganea, Mariana
AU  - Ganea M
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - McDonnell, Kristen
AU  - McDonnell K
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - O'Neill, Diane
AU  - O'Neill D
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Starbuck, Jennifer
AU  - Starbuck J
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Johnson, Eric
AU  - Johnson E
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Meister, Erik
AU  - Meister E
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Pohl, Jonathan
AU  - Pohl J
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Spildener, Jessica
AU  - Spildener J
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Shurtleff, Sheila
AU  - Shurtleff S
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Sovie, Sheryl
AU  - Sovie S
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Melendez, Cathleen
AU  - Melendez C
AD  - Semaphore Solutions, Victoria, British Columbia, Canada.
FAU - Krebs, Pamela
AU  - Krebs P
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Riley, Jacquelyn D
AU  - Riley JD
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Wensel, Christine
AU  - Wensel C
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Astbury, Caroline
AU  - Astbury C
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Azzato, Elizabeth M
AU  - Azzato EM
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Bosler, David S
AU  - Bosler DS
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Brock, Jay E
AU  - Brock JE
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Cook, James R
AU  - Cook JR
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Cheng, Yu-Wei
AU  - Cheng YW
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Tu, Zheng Jin
AU  - Tu ZJ
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Cruise, Michael
AU  - Cruise M
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Henricks, Walter H
AU  - Henricks WH
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Farkas, Daniel H
AU  - Farkas DH
AD  - Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio. Electronic address: farkasd2@ccf.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220131
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
SB  - IM
MH  - Computational Biology
MH  - Humans
MH  - Laboratories
MH  - *Pathology, Molecular
MH  - *Software
MH  - Workflow
EDAT- 2022/02/02 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/02/01 05:49
PHST- 2021/07/12 00:00 [received]
PHST- 2021/12/07 00:00 [revised]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/02 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/02/01 05:49 [entrez]
AID - S1525-1578(22)00012-5 [pii]
AID - 10.1016/j.jmoldx.2022.01.002 [doi]
PST - ppublish
SO  - J Mol Diagn. 2022 May;24(5):503-514. doi: 10.1016/j.jmoldx.2022.01.002. Epub 2022 
      Jan 31.