PMID- 35101622 OWN - NLM STAT- MEDLINE DCOM- 20220608 LR - 20220608 IS - 1873-1597 (Electronic) IS - 1572-1000 (Linking) VI - 38 DP - 2022 Jun TI - Evaluation of the role of spectral-domain optical coherence tomography in the early detection of macular and ganglion cell complex thickness changes in patients with rheumatologic diseases taking hydroxychloroquine. PG - 102741 LID - S1572-1000(22)00030-8 [pii] LID - 10.1016/j.pdpdt.2022.102741 [doi] AB - BACKGROUND: The aim was to investigate the effects of hydroxychloroquine (HCQ) on macular and ganglion cell complex (GCC) thickness measured by spectral-domain optical coherence tomography (SD-OCT). METHODS: A total of 145 patients were included in the study. Patients who had taken HCQ for at least 6 months formed group 1 (n:81), while 34 patients with rheumatologic diseases who did not receive HCQ therapy, and 30 healthy subjects formed groups 2 and 3. The patients in group 1 were divided into two subgroups one with more than 60 months of usage (A), and the other with less than 60 months (B). All patients underwent a complete ophthalmologic examination, as well as visual field (VF) testing, and the measurement of macular and GCC thickness with SD-OCT. RESULTS: The mean duration of taking HCQ was 100.96+/-46.97 and 26.50+/-14.45 months and the total dose was 843.37+/-489.38 g and 208.63+/-135.01 g in groups 1A and 1B, respectively. Patients in group 1 had significantly worse VF scores than groups 2 and 3, but no difference was found between groups 1A and 1B. The SD-OCT macular thickness was thinner in the inner and outer nasal quadrants according to the ETDRS 9 sector chart in the patients using hydroxychloroquine, while the GCC in the group 1A patients was thinner in the superior, inferior areas and inferior inner nasal, inferior-superior outer temporal quadrants compared to the other groups (p < 0.05). CONCLUSION: Assessment of regional macular and GCC changes by SD-OCT is a valuable tool for early detection of HCQ maculopathy. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Aydin Kurna, Sevda AU - Aydin Kurna S AD - Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, Health Science University, Hastane Sokak no:1/8. Icerenkoy, Atasehir, Istanbul 34752, Turkiye. Electronic address: seydaydin@yahoo.com. FAU - Kanar, Hatice Selen AU - Kanar HS AD - Department of Ophthalmology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Health Science University, Cevizli, D-100 Guney Yanyol, Cevizli Mevkii No:47, Kartal, Istanbul 34865, Turkiye. Electronic address: hselensonmez@hotmail.com. FAU - Garli, Murat AU - Garli M AD - Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, Health Science University, Hastane Sokak no:1/8. Icerenkoy, Atasehir, Istanbul 34752, Turkiye. Electronic address: muratgarli@hotmail.com. FAU - Cakir, Necati AU - Cakir N AD - Department of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital, Health Science University, Hastane Sokak no: 1/8. Icerenkoy, Atasehir, Istanbul 34752, Turkiye. Electronic address: necaticakir@hotmail.com. LA - eng PT - Journal Article DEP - 20220131 PL - Netherlands TA - Photodiagnosis Photodyn Ther JT - Photodiagnosis and photodynamic therapy JID - 101226123 RN - 4QWG6N8QKH (Hydroxychloroquine) SB - IM MH - *Arthritis, Rheumatoid/diagnostic imaging/drug therapy MH - Humans MH - Hydroxychloroquine/pharmacology/therapeutic use MH - *Photochemotherapy/methods MH - Retinal Ganglion Cells MH - Tomography, Optical Coherence/methods OTO - NOTNLM OT - Ganglion cell complex thickness OT - Hydroxychloroquine OT - Macular thickness OT - OCT OT - Rheumatology OT - SD-OCT OT - spectral-domain optical coherence tomography EDAT- 2022/02/02 06:00 MHDA- 2022/06/09 06:00 CRDT- 2022/02/01 05:49 PHST- 2021/12/26 00:00 [received] PHST- 2022/01/24 00:00 [revised] PHST- 2022/01/27 00:00 [accepted] PHST- 2022/02/02 06:00 [pubmed] PHST- 2022/06/09 06:00 [medline] PHST- 2022/02/01 05:49 [entrez] AID - S1572-1000(22)00030-8 [pii] AID - 10.1016/j.pdpdt.2022.102741 [doi] PST - ppublish SO - Photodiagnosis Photodyn Ther. 2022 Jun;38:102741. doi: 10.1016/j.pdpdt.2022.102741. Epub 2022 Jan 31.