PMID- 35102728
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20221011
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Print)
IS  - 1083-3668 (Linking)
VI  - 27
IP  - 1
DP  - 2022 Jan
TI  - In vivo safety study using radiation at wavelengths and dosages relevant to 
      intravascular imaging.
LID - 10.1117/1.JBO.27.1.016003 [doi]
LID - 016003
AB  - SIGNIFICANCE: Intravascular photoacoustic (IVPA) imaging can identify native 
      lipid in atherosclerotic plaques in vivo. However, the large number of laser 
      pulses required to produce 3D images is a safety concern that has not been fully 
      addressed. AIM: We aim to evaluate if irradiation at wavelengths and dosages 
      relevant to IVPA imaging causes target vessel damage. APPROACH: We irradiate the 
      carotid artery of swine at one of several energy dosages using radiation at 1064 
      or 1720 nm and use histological evaluation by a pathologist to identify 
      dose-dependent damage. RESULTS: Media necrosis was the only dose-dependent form 
      of injury. Damage was present at a cumulative fluence of 50  J  /  cm2 when using 
      1720 nm light. Damage was more equivocally identified at 700  J  /  cm2 using 
      1064 nm. CONCLUSIONS: In prior work, IVPA imaging of native lipid in swine has 
      been successfully conducted below the damage thresholds identified. This 
      indicates that it will be possible to use IVPA imaging in a clinical setting 
      without damaging vessel tissue. Future work should determine if irradiation 
      causes an increase in blood thrombogenicity and confirm whether damaged tissue 
      will heal over longer time points.
FAU - Sowers, Timothy
AU  - Sowers T
AD  - Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and 
      Bioscience, Atlant, United States.
AD  - Georgia Institute of Technology, George W. Woodruff School of Mechanical 
      Engineering, Atlanta, Georg, United States.
FAU - VanderLaan, Don
AU  - VanderLaan D
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
FAU - Karpiouk, Andrei
AU  - Karpiouk A
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
FAU - Onohara, Daisuke
AU  - Onohara D
AD  - Emory University Hospital Midtown, Structural Heart Research and Innovation 
      Laboratory, Carlyle Fras, United States.
FAU - Schmarkey, Susan
AU  - Schmarkey S
AD  - Emory University Hospital Midtown, Structural Heart Research and Innovation 
      Laboratory, Carlyle Fras, United States.
FAU - Rousselle, Serge
AU  - Rousselle S
AD  - StageBio, Mt. Jackson, Virginia, United States.
FAU - Padala, Muralidhar
AU  - Padala M
AD  - Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and 
      Bioscience, Atlant, United States.
AD  - Emory University Hospital Midtown, Structural Heart Research and Innovation 
      Laboratory, Carlyle Fras, United States.
AD  - Georgia Institute of Technology and Emory University School of Medicine, Wallace 
      H. Coulter Departme, United States.
FAU - Emelianov, Stanislav
AU  - Emelianov S
AD  - Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and 
      Bioscience, Atlant, United States.
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
AD  - Georgia Institute of Technology and Emory University School of Medicine, Wallace 
      H. Coulter Departme, United States.
LA  - eng
GR  - R01 HL124417/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Animals
MH  - Diagnostic Imaging
MH  - Lasers
MH  - *Plaque, Atherosclerotic
MH  - Swine
PMC - PMC8802906
OTO - NOTNLM
OT  - imaging
OT  - in vivo
OT  - intravascular
OT  - laser
OT  - photoacoustics
OT  - safety
EDAT- 2022/02/02 06:00
MHDA- 2022/03/15 06:00
PMCR- 2022/01/31
CRDT- 2022/02/01 06:13
PHST- 2021/08/08 00:00 [received]
PHST- 2022/01/05 00:00 [accepted]
PHST- 2022/02/01 06:13 [entrez]
PHST- 2022/02/02 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/01/31 00:00 [pmc-release]
AID - JBO-210251R [pii]
AID - 210251R [pii]
AID - 10.1117/1.JBO.27.1.016003 [doi]
PST - ppublish
SO  - J Biomed Opt. 2022 Jan;27(1):016003. doi: 10.1117/1.JBO.27.1.016003.