PMID- 35106610
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220517
IS  - 1435-5604 (Electronic)
IS  - 0914-8779 (Linking)
VI  - 40
IP  - 3
DP  - 2022 May
TI  - Sexual dimorphism in the relation between sex hormones and osteoporosis in 
      patients with type 2 diabetes mellitus.
PG  - 460-467
LID - 10.1007/s00774-021-01291-6 [doi]
AB  - INTRODUCTION: To investigate the association between sex hormones and 
      osteoporosis in type 2 diabetic mellitus (T2DM) patients. MATERIALS AND METHODS: 
      We performed a retrospective study in patients with T2DM. The patients were 
      assigned into three groups (normal bone mineral density, osteopenia, and 
      osteoporosis) in both sexes. The clinical characteristics, bone metabolic 
      markers, and sex hormones were compared. The relationship between the sex 
      hormones and osteoporosis was analyzed by ordinary regression analysis. 
      Statistical analysis was performed using SPSS 26.0. RESULTS: A total of 795 T2DM 
      patients (446 men >/= 50 years old and 349 postmenopausal women) were identified 
      and analyzed. The osteoporosis group had the lowest estradiol level in men 
      (P = 0.013) and the highest follicle-stimulating hormone (FSH) level in women 
      (P = 0.042). In the multivariate analysis, men with lower estradiol levels 
      (< 87.96 pmol/L) had a nearly 1.6-fold increased risk for osteoporosis than those 
      with the higher estradiol levels (> 122.82 pmol/L). In addition, women with lower 
      FSH (< 41.17 IU/L) had nearly 0.6-fold for osteoporosis compared to those with 
      higher FSH (> 60.83 IU/L) after adjusting for age, duration of T2DM, body mass 
      index, pulse pressure, creatinine clearance, glycosylated hemoglobin, fasting 
      C-peptide, and estradiol (in FSH) or FSH (in estradiol). CONCLUSION: In T2DM, the 
      estrogen level was negatively correlated with osteoporosis in men, and the FSH 
      level was positively correlated with the osteoporosis in women.
CI  - (c) 2022. The Japanese Society Bone and Mineral Research.
FAU - Ran, Cui
AU  - Ran C
AUID- ORCID: 0000-0003-4386-3140
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai, China.
FAU - Xiaojuan, Xu
AU  - Xiaojuan X
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai, China.
FAU - Wenxue, Gao
AU  - Wenxue G
AD  - Medical Services Section, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China. gaowx2000@163.com.
FAU - Zhaoliang, Fei
AU  - Zhaoliang F
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai, China. feiz@sibcb.ac.cn.
FAU - Hui, Sheng
AU  - Hui S
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai, China. shenghui@tongji.edu.cn.
FAU - Shen, Qu
AU  - Shen Q
LA  - eng
GR  - NFSC 81500650/National Natural Science Foundation of China/
GR  - 2018SYPDRC049/"Climbing" Program of Shanghai Tenth People's Hospital of Tongji 
      University/
PT  - Journal Article
DEP - 20220202
PL  - Japan
TA  - J Bone Miner Metab
JT  - Journal of bone and mineral metabolism
JID - 9436705
RN  - 0 (Gonadal Steroid Hormones)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Bone Density
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Estradiol
MH  - Female
MH  - Follicle Stimulating Hormone
MH  - Gonadal Steroid Hormones
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Osteoporosis/etiology
MH  - Retrospective Studies
MH  - Sex Characteristics
OTO - NOTNLM
OT  - Bone mineral density
OT  - Diabetes
OT  - Estrogen
OT  - Follicle-stimulating hormone
OT  - Osteoporosis
EDAT- 2022/02/03 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/02/02 05:36
PHST- 2021/03/11 00:00 [received]
PHST- 2021/11/09 00:00 [accepted]
PHST- 2022/02/03 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/02/02 05:36 [entrez]
AID - 10.1007/s00774-021-01291-6 [pii]
AID - 10.1007/s00774-021-01291-6 [doi]
PST - ppublish
SO  - J Bone Miner Metab. 2022 May;40(3):460-467. doi: 10.1007/s00774-021-01291-6. Epub 
      2022 Feb 2.