PMID- 35108587
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220414
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 116
DP  - 2022 Jun 8
TI  - Alterations of default mode and cingulo-opercular salience network and 
      frontostriatal circuit: A candidate endophenotype of obsessive-compulsive 
      disorder.
PG  - 110516
LID - S0278-5846(22)00008-2 [pii]
LID - 10.1016/j.pnpbp.2022.110516 [doi]
AB  - Background It is gradually becoming clear that obsessive-compulsive disorder 
      (OCD) patients have aberrant resting-state large-scale intrinsic networks of 
      cingulo-opercular salience (SN), default mode (DMN), and front-parietal network 
      (FPN). However, it remains unknown whether unaffected first-degree relatives of 
      OCD patients have these alterations as a vulnerability marker to the disorder. 
      Methods We performed resting-state functional magnetic resonance imaging (rsfMRI) 
      scans of 47 medication-free OCD patients, 21 unaffected healthy first-degree 
      relatives of OCD patients, and 62 healthy control (HC) participants. We explored 
      differences between the three groups in the functional connectivity from SN 
      (seeds: anterior-insula (AI) and dorsal anterior cingulate cortex (dACC)), DMN 
      (seeds: medial prefrontal cortex (MPFC) and posterior parietal cortex (PCC)), and 
      FPN (seeds: dorsolateral prefrontal cortex (DLPFC)). Results Compared to HC, both 
      OCD patients and first-degree relatives showed significantly greater functional 
      connectivity between AI and PCC and between DLPFC and the thalamus. Compared to 
      first-degree relatives and HC, OCD patients showed reduced functional 
      connectivity between PCC and DLPFC, and this altered functional connectivity was 
      negatively correlated with anxiety and depressive symptom within OCD group. 
      Conclusions OCD patients and unaffected first-degree relatives of OCD patients 
      showed overlapping alterations in resting state functional connectivity between 
      the regions of SN and DMN and between DLPFC and the thalamus. Our results 
      suggested that alterations between large-scale intrinsic networks and within the 
      dorsal cognitive cortico-striato-thalamo-cortical (CSTC) circuit could represent 
      endophenotype markers of OCD.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Tomiyama, Hirofumi
AU  - Tomiyama H
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Murayama, Keitaro
AU  - Murayama K
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Nemoto, Kiyotaka
AU  - Nemoto K
AD  - Department of Psychiatry, Faculty of Medicine, University of Tsukuba, Japan.
FAU - Hasuzawa, Suguru
AU  - Hasuzawa S
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Mizobe, Taro
AU  - Mizobe T
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Kato, Kenta
AU  - Kato K
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Matsuo, Akira
AU  - Matsuo A
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Ohno, Aikana
AU  - Ohno A
AD  - Department of Psychology, Kyushu University, Japan.
FAU - Kang, Mingi
AU  - Kang M
AD  - Department of Psychology, Kyushu University, Japan.
FAU - Togao, Osamu
AU  - Togao O
AD  - Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, 
      Kyushu University, Japan.
FAU - Hiwatashi, Akio
AU  - Hiwatashi A
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Ishigami, Kousei
AU  - Ishigami K
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Nakao, Tomohiro
AU  - Nakao T
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan. Electronic address: tomona@npsych.med.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220130
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Brain Mapping
MH  - *Endophenotypes
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
MH  - *Obsessive-Compulsive Disorder/diagnostic imaging/genetics
MH  - Thalamus
OTO - NOTNLM
OT  - And front-parietal network
OT  - Cingulo-opercular salience network
OT  - Cortico-striato-thalamo-cortical circuit
OT  - Default mode network
OT  - Endophenotypes
OT  - Obsessive-compulsive disorder
OT  - Resting state functional MRI
EDAT- 2022/02/03 06:00
MHDA- 2022/04/15 06:00
CRDT- 2022/02/02 20:06
PHST- 2021/10/19 00:00 [received]
PHST- 2022/01/04 00:00 [revised]
PHST- 2022/01/20 00:00 [accepted]
PHST- 2022/02/03 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/02/02 20:06 [entrez]
AID - S0278-5846(22)00008-2 [pii]
AID - 10.1016/j.pnpbp.2022.110516 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 8;116:110516. doi: 
      10.1016/j.pnpbp.2022.110516. Epub 2022 Jan 30.