PMID- 35108660 OWN - NLM STAT- MEDLINE DCOM- 20220523 LR - 20220607 IS - 1878-1810 (Electronic) IS - 1878-1810 (Linking) VI - 244 DP - 2022 Jun TI - Allergic asthma aggravates angiotensin Ⅱ-induced cardiac remodeling in mice. PG - 88-100 LID - S1931-5244(22)00018-4 [pii] LID - 10.1016/j.trsl.2022.01.005 [doi] AB - Cardiovascular disease remains the leading cause of death globally, and heart failure (HF) represents its terminal stage. Asthma, one of the most common chronic diseases, has been reported to be associated with an increased risk of cardiovascular disease. However, the link between asthma and HF has rarely been studied, and the possible mechanisms by which asthma affects HF are unclear. This study aimed to explore the influence of asthma on HF and the possible mechanisms. We analyzed data from the National Health and Nutrition Examination Survey and found a higher prevalence of HF among asthmatic individuals, and identified an independent association between HF and asthma. Subsequently, we produced mice with concurrent ovalbumin (OVA) sensitization-induced allergic asthma and angiotensin Ⅱ infusion-induced cardiac remodeling to explore the effect of asthma on cardiac remodeling in vivo. The results showed that OVA-induced asthma impaired heart function and aggravated cardiac remodeling in mice. We also found that OVA sensitization increased the expression levels of immunoglobulin E (IgE) in serum and IgE receptor (FcepsilonR1) in the heart, and enhanced the activation of downstream signaling molecules of IgE-FcepsilonR1 in the heart. Importantly, blockage of IgE-FcepsilonR1 using FcepsilonR1-deficient mice or an anti-IgE antibody prevented asthma-induced decline of cardiac function, and alleviated cardiac remodeling. These findings demonstrate the adverse effects of allergic asthma on the heart, and suggest the potential application of anti-IgE therapy in the treatment of asthma complicated with heart conditions. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Geng, Chi AU - Geng C AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Feng, Yufan AU - Feng Y AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Yang, Yang AU - Yang Y AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Yang, Hongqin AU - Yang H AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Li, Zhiwei AU - Li Z AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Tang, Yaqin AU - Tang Y AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Wang, Jing AU - Wang J AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. Electronic address: wangjing@ibms.pumc.edu.cn. FAU - Zhao, Hongmei AU - Zhao H AD - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. Electronic address: hongmeizhao@ibms.pumc.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220131 PL - United States TA - Transl Res JT - Translational research : the journal of laboratory and clinical medicine JID - 101280339 RN - 11128-99-7 (Angiotensin II) RN - 37341-29-0 (Immunoglobulin E) RN - 9006-59-1 (Ovalbumin) SB - IM MH - Angiotensin II MH - Animals MH - *Asthma MH - Bronchoalveolar Lavage Fluid MH - *Cardiovascular Diseases/complications MH - Disease Models, Animal MH - *Heart Failure/complications MH - Immunoglobulin E MH - Mice MH - Mice, Inbred BALB C MH - Nutrition Surveys MH - Ovalbumin/adverse effects MH - Ventricular Remodeling OTO - NOTNLM OT - AKT, protein kinase B OT - ANP, natriuretic peptide type A OT - Ang Ⅱ, angiotensin Ⅱ OT - BALF, bronchioalveolar lavage fluid OT - BMI, body mass index OT - BNP, natriuretic peptide type B OT - BW, body weight OT - CAD, coronary heart disease OT - COPD, chronic obstructive pulmonary disease OT - CVD, cardiovascular disease OT - EF, ejection fraction OT - FS, fraction shortening OT - HF, heart failure OT - HW, heart weight OT - IgE, immunoglobulin E OT - LVAW, left ventricular anterior wall OT - LVID, left ventricular internal dimension OT - LVPW, left ventricular posterior wall OT - NHANES, National Health and Nutrition Examination Survey OT - OVA, ovalbumin OT - TC, total cholesterol OT - TG, triglyceride OT - WGA, wheat germ agglutinin OT - WT, wild type OT - pSmad2/3, phosphorylated small mothers against decapentaplegic 2 and 3 OT - alpha-SMA, alpha-smooth muscle actin OT - beta-MHC, beta-myosin heavy chain EDAT- 2022/02/03 06:00 MHDA- 2022/05/24 06:00 CRDT- 2022/02/02 20:06 PHST- 2021/08/30 00:00 [received] PHST- 2022/01/13 00:00 [revised] PHST- 2022/01/24 00:00 [accepted] PHST- 2022/02/03 06:00 [pubmed] PHST- 2022/05/24 06:00 [medline] PHST- 2022/02/02 20:06 [entrez] AID - S1931-5244(22)00018-4 [pii] AID - 10.1016/j.trsl.2022.01.005 [doi] PST - ppublish SO - Transl Res. 2022 Jun;244:88-100. doi: 10.1016/j.trsl.2022.01.005. Epub 2022 Jan 31.