PMID- 35108738
OWN - NLM
STAT- MEDLINE
DCOM- 20221221
LR  - 20230112
IS  - 1439-1902 (Electronic)
IS  - 0171-6425 (Linking)
VI  - 70
IP  - 8
DP  - 2022 Dec
TI  - Outcome of Surgery for Chronic Thromboembolic Pulmonary Disease without Pulmonary 
      Hypertension.
PG  - 658-662
LID - 10.1055/s-0041-1740560 [doi]
AB  - BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious 
      condition that results from incomplete resolution of thromboemboli in pulmonary 
      arteries. Symptomatic patients with chronic thromboembolic disease may have 
      normal hemodynamic at rest. The aim of this study is to evaluate the outcome of 
      pulmonary endarterectomy (PEA) in symptomatic patients with chronic 
      thromboembolic pulmonary disease (CTEPD) in the absence of pulmonary hypertension 
      as currently defined (mean pulmonary artery pressure [mPAP] < 20 mm Hg). PATIENTS 
      AND METHODS: Here, we report four symptomatic patients with chronic 
      thromboembolic and normal hemodynamic at rest (mPAP </=20 mm Hg or 
      20 < mPAP < 25 mm Hg and pulmonary vascular resistance [PVR] < 240 dyn.s/cm(5)) 
      who underwent PEA between September 2015 and September 2019. The main outcome 
      measures were functional New York Heart Association class, 6-minute walk distance 
      (6MWD), hemodynamic measures in right heart catheterization (RHC), morbidity, and 
      mortality. RESULTS: There were significant improvement in function class 
      (2.6 +/- 0.54 vs. 1 +/- 0.2, p = 0.00), mPAP (preoperative: 23.3 +/- 0.5 mm Hg vs. 
      postoperative: 18.6 +/- 1.5 mm Hg, p = 0.02), 6MWD (preoperative: 378.2 +/- 68.7 m 
      vs. postoperative: 432.9 +/- 44.5 m, p = 0.01), and PVR (215.33 +/- 91 vs. 101 +/- 32 
      dyn.s/cm(5), p = 0.1) 6 months after surgery based on data from RHC which was 
      done during exercise. Also, RHC showed a significant decrease in mPAP 
      (preoperative: 37 +/- 7.7 mm Hg vs. postoperative 28 +/- 3.2 mm Hg, p = 0.06). 
      CONCLUSION: PEA could improve function class and hemodynamic in patients with 
      CTEPD. Considering hemodynamic improvement in this group of patients after PEA, 
      definition of CTEPH may need to be revised.
CI  - Thieme. All rights reserved.
FAU - Rashidi, Farid
AU  - Rashidi F
AD  - Tuberculosis and Lung Disease Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Parvizi, Rezayat
AU  - Parvizi R
AD  - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Bilejani, Eisa
AU  - Bilejani E
AD  - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Mahmoudian, Babak
AU  - Mahmoudian B
AD  - Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Koohi, Ata
AU  - Koohi A
AUID- ORCID: 0000-0001-6421-1606
AD  - Tuberculosis and Lung Disease Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220202
PL  - Germany
TA  - Thorac Cardiovasc Surg
JT  - The Thoracic and cardiovascular surgeon
JID - 7903387
SB  - IM
MH  - Humans
MH  - *Hypertension, Pulmonary
MH  - *Pulmonary Embolism
MH  - Treatment Outcome
MH  - Pulmonary Artery
MH  - Hemodynamics
MH  - Chronic Disease
MH  - *Thromboembolism
MH  - Endarterectomy
COIS- None declared.
EDAT- 2022/02/03 06:00
MHDA- 2022/12/22 06:00
CRDT- 2022/02/02 20:07
PHST- 2022/02/03 06:00 [pubmed]
PHST- 2022/12/22 06:00 [medline]
PHST- 2022/02/02 20:07 [entrez]
AID - 10.1055/s-0041-1740560 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg. 2022 Dec;70(8):658-662. doi: 10.1055/s-0041-1740560. Epub 
      2022 Feb 2.