PMID- 35109804
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220206
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Feb 2
TI  - Functional connectivity density alterations in children with strabismus and 
      amblyopia based on resting-state functional magnetic resonance imaging (fMRI).
PG  - 49
LID - 10.1186/s12886-021-02228-3 [doi]
LID - 49
AB  - PURPOSE: To explore functional connectivity density (FCD) values of brain areas 
      in children with strabismus and amblyopia (SA) based on blood oxygen 
      level-dependent (BOLD) signals. METHODS: This study recruited 26 children (14 
      male, 12 females) with SA and 26 healthy children (14 male, 12 female) as healthy 
      controls (HCs). Both groups matched in age, gender, educational level and 
      socioeconomic background. While resting, all participants underwent fMRI scanning 
      and global FCD (gFCD) and local FCD (lFCD) values were calculated. Receiver 
      operating characteristic (ROC) curves were created to investigate whether there 
      was a significant difference between children with SA and healthy controls. 
      RESULTS: When compared with healthy controls, children with SA had significantly 
      lower gFCD values in the right cerebellum, left putamen, and right superior 
      frontal gyrus; however, the same metrics showed opposite changes in the right 
      angular gyrus, left middle cingulate gyrus, left angular gyrus, right superior 
      parietal gyrus, and right middle frontal gyrus. In children with SA, lFCD values 
      were found to be remarkably decreased in regions of the middle right temporal 
      pole, right cerebellum, left putamen, left hippocampus, right hippocampus, left 
      thalamus, left cerebellum; values were increased in the right superior parietal 
      gyrus as compared with healthy controls. CONCLUSION: We noted abnormal neural 
      connectivity in some brain areas of children with SA; detailing such connectivity 
      aberrations is useful in exploring the pathophysiology of SA and providing useful 
      information for future clinical management.
CI  - (c) 2022. The Author(s).
FAU - Shi, Yi-Dan
AU  - Shi YD
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Ge, Qian-Min
AU  - Ge QM
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Lin, Qi
AU  - Lin Q
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Liang, Rong-Bin
AU  - Liang RB
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Li, Qiu-Yu
AU  - Li QY
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Shi, Wen-Qing
AU  - Shi WQ
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Li, Biao
AU  - Li B
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China.
FAU - Shao, Yi
AU  - Shao Y
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, 
      YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's 
      Republic of China. freebee99@163.com.
LA  - eng
PT  - Journal Article
DEP - 20220202
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - *Amblyopia/diagnostic imaging
MH  - Brain/diagnostic imaging
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Strabismus
PMC - PMC8808980
OTO - NOTNLM
OT  - Amblyopia
OT  - Magnetic resonance imaging
OT  - Strabismus
COIS- This was not an industry supported study. The authors report no conflicts of 
      interest in this work.
EDAT- 2022/02/04 06:00
MHDA- 2022/02/05 06:00
PMCR- 2022/02/02
CRDT- 2022/02/03 05:27
PHST- 2021/07/26 00:00 [received]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2022/02/03 05:27 [entrez]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2022/02/02 00:00 [pmc-release]
AID - 10.1186/s12886-021-02228-3 [pii]
AID - 2228 [pii]
AID - 10.1186/s12886-021-02228-3 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2022 Feb 2;22(1):49. doi: 10.1186/s12886-021-02228-3.