PMID- 35109884
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220328
IS  - 1749-8090 (Electronic)
IS  - 1749-8090 (Linking)
VI  - 17
IP  - 1
DP  - 2022 Feb 2
TI  - Growth rate of ascending thoracic aortic aneurysms in a non-referral-based 
      population.
PG  - 14
LID - 10.1186/s13019-022-01761-6 [doi]
LID - 14
AB  - BACKGROUND: Prior studies on ascending thoracic aortic aneurysm (ATAA) growth 
      rates have reported approximately 1 mm of growth per year but these studies are 
      based on referral-based study populations which are biased towards the highest 
      risk patients who may not represent the true natural history of aortic aneurysm 
      disease. We aimed to characterize the growth rate of ATAAs in a 
      non-referral-based population, using a large institutional database of computed 
      tomography (CT) scans. METHODS: We queried the 21,325 CT scans performed at our 
      institution between 2013 and 2016 on patients ages 50-85 years old for radiologic 
      diagnosis of aortic aneurysm or dilatation. 560 patients were identified to have 
      aortic dilatation > 4 cm, of which 207 had follow-up scan intervals > 6 months. 
      This comprised our non-referral-based study population. Linearized annual 
      aneurysm growth rates were calculated by dividing the change in aortic size by 
      the time interval between CT scans. RESULTS: The median time interval between 
      scans was 2.7 years (interquartile range [IQR] 1.5-4.2) for the 207 patients 
      included in the study. The median initial aneurysm size was 4.3 cm (IQR 4.1-4.5). 
      38.2% (n = 79) of patients did not experience aortic dilatation. The median 
      growth rate was 0.13 mm/year (IQR - 0.24 to 0.49). Of patients in the top 
      quartile of growth rates, 26.9% of patients were female whereas 12.9% of patients 
      were female in the bottom three quartiles of growth rates. CONCLUSION: While some 
      patients' ATAAs may grow at previously published rates of around 1 mm/year, this 
      is not the predominant pattern in a non-referral-based population and may 
      over-estimate the overall growth rate of ATAAs.
CI  - (c) 2022. The Author(s).
FAU - Weininger, Gabe
AU  - Weininger G
AUID- ORCID: 0000-0002-3477-7526
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA.
FAU - Mori, Makoto
AU  - Mori M
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA.
FAU - Yousef, Sameh
AU  - Yousef S
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA.
FAU - Hur, David J
AU  - Hur DJ
AD  - Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
FAU - Assi, Roland
AU  - Assi R
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA.
FAU - Geirsson, Arnar
AU  - Geirsson A
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA.
FAU - Vallabhajosyula, Prashanth
AU  - Vallabhajosyula P
AD  - Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, 
      Boardman Building 204L, New Haven, CT, 06520, USA. 
      prashanth.vallabhajosyula@yale.edu.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Letter
DEP - 20220202
PL  - England
TA  - J Cardiothorac Surg
JT  - Journal of cardiothoracic surgery
JID - 101265113
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aorta
MH  - *Aortic Aneurysm
MH  - *Aortic Aneurysm, Thoracic/diagnostic imaging/epidemiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Referral and Consultation
MH  - Tomography, X-Ray Computed
PMC - PMC8812194
OTO - NOTNLM
OT  - Ascending aortic aneurysm
OT  - Computed tomography
OT  - Growth rate
OT  - Referrel based population
COIS- The authors declare no competing interests.
EDAT- 2022/02/04 06:00
MHDA- 2022/02/05 06:00
PMCR- 2022/02/02
CRDT- 2022/02/03 05:28
PHST- 2021/05/26 00:00 [received]
PHST- 2022/01/22 00:00 [accepted]
PHST- 2022/02/03 05:28 [entrez]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2022/02/02 00:00 [pmc-release]
AID - 10.1186/s13019-022-01761-6 [pii]
AID - 1761 [pii]
AID - 10.1186/s13019-022-01761-6 [doi]
PST - epublish
SO  - J Cardiothorac Surg. 2022 Feb 2;17(1):14. doi: 10.1186/s13019-022-01761-6.