PMID- 35110337
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220830
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 43
IP  - 2
DP  - 2022 Feb
TI  - Lack of association between fat mass and obesity-associated genetic variant 
      (rs8050136) and type 2 diabetes mellitus.
PG  - 132-138
LID - 10.15537/smj.2022.43.2.20210822 [doi]
AB  - OBJECTIVES: To study the genotype and allele frequency of the fat mass and 
      obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its 
      association with type 2 diabetes mekkitus (T2DM) parameters. METHODS: This study 
      was carried out on 118 diabetic patients and 106 healthy individuals (control) 
      from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi 
      Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used 
      for rs8050136 genotyping. RESULTS: The frequency of the genotype AA was the same 
      among T2DM and healthy control groups (21%). However, the frequency of genotype 
      CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no 
      significant association between FTO SNP rs8050136 and an increased risk of T2DM. 
      Furthermore, there was no association between the risk AA genotype and fasting 
      blood glucose (p=0.092), glycated hemoglobin (p=0.177), or body mass index 
      (p=0.561). CONCLUSION: Our findings show that the FTO rs8050136 A>C variant is 
      not associated with T2DM in the Saudi population.
CI  - Copyright: (c) Saudi Medical Journal.
FAU - Yousuf, Amjad M
AU  - Yousuf AM
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Kannu, Firoz A
AU  - Kannu FA
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Youssouf, Talha M
AU  - Youssouf TM
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Alsuhaimi, Fatimah N
AU  - Alsuhaimi FN
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Aljohani, Abdulaziz M
AU  - Aljohani AM
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Alsehli, Fayez H
AU  - Alsehli FH
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Khabour, Omar F
AU  - Khabour OF
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Almutawif, Yahya A
AU  - Almutawif YA
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Najim, Mustafa A
AU  - Najim MA
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Mahmood, Hatem A
AU  - Mahmood HA
AD  - From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, 
      Najim), College of Applied Medical Sciences, Taibah University; from the General 
      Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from 
      the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and 
      Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz 
      Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the 
      Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical 
      Sciences, Jordan University of Science and Technology, Irbid, Jordan.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
SB  - IM
CIN - Saudi Med J. 2022 Apr;43(4):431-432. PMID: 35414624
MH  - *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Saudi Arabia
PMC - PMC9127913
OTO - NOTNLM
OT  - FTO gene
OT  - GWAS
OT  - allele frequency
OT  - gene variant
OT  - type 2 diabetes
EDAT- 2022/02/04 06:00
MHDA- 2022/02/05 06:00
PMCR- 2022/02/01
CRDT- 2022/02/03 05:29
PHST- 2021/10/09 00:00 [received]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2022/02/03 05:29 [entrez]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 43/2/132 [pii]
AID - SaudiMedJ-43-132 [pii]
AID - 10.15537/smj.2022.43.2.20210822 [doi]
PST - ppublish
SO  - Saudi Med J. 2022 Feb;43(2):132-138. doi: 10.15537/smj.2022.43.2.20210822.