PMID- 35111074
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Elevated Peripheral Brain-Derived Neurotrophic Factor Level Associated With 
      Decreasing Insulin Secretion May Forecast Memory Dysfunction in Patients With 
      Long-Term Type 2 Diabetes.
PG  - 686838
LID - 10.3389/fphys.2021.686838 [doi]
LID - 686838
AB  - BACKGROUND: With the progressive course of diabetes and the decline in islet 
      function, the cognitive dysfunction of patients aggravated. OBJECTIVE: We aimed 
      to investigate the roles of brain-derived neurotrophic factor (BDNF) and the 
      Val66Met polymorphism in mild cognitive impairment (MCI) in patients with type 2 
      diabetes mellitus (T2DM). METHODS: A total of 169 Chinese patients with T2DM were 
      involved and divided into long-term (diabetes duration >10 years) and short-term 
      (diabetes duration </=10 years) diabetes, and in each group, the patients were 
      separated as MCI and the control. Demographic characteristics, clinical 
      variables, and cognitive performances were assessed. The plasma BDNF level was 
      measured via enzyme-linked immunosorbent assay. The Val66Met polymorphisms were 
      analyzed. RESULTS: Long-term T2DM have lower 2 h postprandial C-peptide (p < 
      0.05). The BDNF level was slightly higher in patients with MCI than in the 
      controls in each duration group without statistical significance. The 
      relationship of BDNF to Montreal Cognitive Assessment was not proven either. 
      However, in the long-term diabetes group, BDNF concentration remained as an 
      independent factor of logical memory test (beta = -0.27; p < 0.05), and they were 
      negatively correlated (r = -0.267; p = 0.022); BDNF was also negatively 
      correlated with fasting C-peptide (r = -0.260; p = 0.022), 2 h postprandial 
      C-peptide (r = -0.251; p = 0.028), and homeostasis model assessment of insulin 
      resistance (r = -0.312; p = 0.006). In genotypic groups, BDNF Val/Val performed 
      better in logical memory test than Met/Met and Val/Met. CONCLUSION: Elevated 
      peripheral BDNF level associated with declined islet function, when combined with 
      its Val66Met polymorphism, may forecast memory dysfunction in patients with 
      long-term T2DM.
CI  - Copyright (c) 2022 Huang, Xie, Wang and Wang.
FAU - Huang, Xi
AU  - Huang X
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - Nanjing Medical University, Nanjing, China.
FAU - Xie, Zuolin
AU  - Xie Z
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Chenchen
AU  - Wang C
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - Nanjing Medical University, Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20220117
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC8801615
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - insulin
OT  - islet
OT  - mild cognition impairment
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/04 06:00
MHDA- 2022/02/04 06:01
PMCR- 2022/01/17
CRDT- 2022/02/03 05:33
PHST- 2021/03/28 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/02/03 05:33 [entrez]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/02/04 06:01 [medline]
PHST- 2022/01/17 00:00 [pmc-release]
AID - 10.3389/fphys.2021.686838 [doi]
PST - epublish
SO  - Front Physiol. 2022 Jan 17;12:686838. doi: 10.3389/fphys.2021.686838. eCollection 
      2021.