PMID- 35111505
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2189-7255 (Electronic)
IS  - 2189-7247 (Print)
IS  - 2189-7247 (Linking)
VI  - 5
IP  - 3
DP  - 2019
TI  - Preliminary therapeutic outcomes of using direct oral anticoagulants to treat 
      venous thromboembolism in gynecological cancer patients.
PG  - 67-71
LID - 10.20407/fmj.2018-012 [doi]
AB  - OBJECTIVES: Venous thromboembolism (VTE) is often a problematic complication in 
      patients with gynecological cancer. Despite increasing opportunities to use 
      direct oral anticoagulants (DOACs) to treat VTE, there are no reports on the 
      therapeutic outcomes of DOACs in patients with gynecological cancer; however, 
      there are some studies on cancer patients in general. We retrospectively examined 
      the efficacy and safety of using DOACs to treat VTE in such patients. METHODS: 
      The study cohort comprised 43 patients with gynecological cancer and VTE who 
      received treatment between May 2005 and April 2016. They were divided into two 
      groups: DOACs used (DOAC group, n=21) and only unfractionated heparin (UFH) and 
      warfarin used (standard group, n=22). The rates of improvement and recurrence of 
      VTE and incidence of adverse events were compared between these groups. RESULTS: 
      At 6 months, the VTE of 85% of patients in the DOAC group and of 75% in the 
      standard group had improved (p=0.59). No recurrences of VTE occurred in the DOAC 
      group; where VTE recurred in 12.5% of patients in the standard group. Adverse 
      events occurred in three patients in the DOAC group (15.3%) and one in the 
      standard group (7.7%). Chemotherapy significantly impacted improvement in VTE 
      (p=0.01). CONCLUSIONS: Rates of VTE improvement and of recurrence of VTE and 
      adverse events did not differ significantly between the study groups.
FAU - Osaki, Sayaka
AU  - Osaki S
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Kawai, Satoshi
AU  - Kawai S
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Ito, Mayuko
AU  - Ito M
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Otani, Sayaka
AU  - Otani S
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Ichikawa, Ryoko
AU  - Ichikawa R
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Torii, Yutaka
AU  - Torii Y
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
FAU - Takahashi, Hiroshi
AU  - Takahashi H
AD  - Faculty of Rehabilitation, Fujita Health University, School of Health Sciences, 
      Toyoake, Aichi, Japan.
FAU - Toyama, Hiroshi
AU  - Toyama H
AD  - Department of Radiology, Fujita Health University, School of Medicine, Toyoake, 
      Aichi, Japan.
FAU - Ozaki, Yukio
AU  - Ozaki Y
AD  - Department of Cardiology, Fujita Health University, School of Medicine, Toyoake, 
      Aichi, Japan.
FAU - Fujii, Takuma
AU  - Fujii T
AD  - Department of Obstetrics and Gynecology, Fujita Health University, School of 
      Medicine, Toyoake, Aichi, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190417
PL  - Japan
TA  - Fujita Med J
JT  - Fujita medical journal
JID - 101745077
PMC - PMC8766242
OTO - NOTNLM
OT  - Direct oral anticoagulants
OT  - Gynecological cancer
OT  - Venous thromboembolism
EDAT- 2019/01/01 00:00
MHDA- 2019/01/01 00:01
PMCR- 2019/04/17
CRDT- 2022/02/03 05:34
PHST- 2018/07/27 00:00 [received]
PHST- 2019/01/18 00:00 [accepted]
PHST- 2022/02/03 05:34 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2019/01/01 00:01 [medline]
PHST- 2019/04/17 00:00 [pmc-release]
AID - 10.20407/fmj.2018-012 [doi]
PST - ppublish
SO  - Fujita Med J. 2019;5(3):67-71. doi: 10.20407/fmj.2018-012. Epub 2019 Apr 17.