PMID- 35112019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2451-9936 (Electronic)
IS  - 2451-9936 (Linking)
VI  - 25
DP  - 2022 Mar
TI  - Obscured interdigitation zone at the early stage of gyrate atrophy: A case 
      report.
PG  - 101277
LID - 10.1016/j.ajoc.2022.101277 [doi]
LID - 101277
AB  - PURPOSE: To report an early stage of gyrate atrophy (GA) of the retina and 
      choroid for which spectral-domain optical coherence tomography (SD-OCT) images 
      revealed an obscured interdigitation zone (IZ). OBSERVATION: A 13-year-old boy 
      was referred to our department due to blurred vision in his left eye. Best 
      corrected visual acuity was 20/20 and 20/25 in the right and left eye, 
      respectively. Fundus examination revealed scalloped atrophic peripheral 
      chorioretinal lesions in both eyes. Concentrations of plasma and urine ornithine 
      were 1192 nmol/mL and 1930 mumol/g.cre, respectively. Consequently, he was 
      diagnosed with GA. Although Goldmann perimetry found no abnormalities, 
      electroretinogram (ERG) revealed loss of the rod responses and significant 
      attenuation of the cone responses in both eyes. Detailed analysis of the 
      posterior part of the fundus using multifocal electroretinogram showed poor 
      responses, specifically in the nasal macular area of the left eye. SD-OCT showed 
      an obscured IZ corresponding to the attenuated cone response determined by ERG. 
      There was preservation of the retinal pigment epithelium, ellipsoid zone and 
      external limiting membrane. CONCLUSIONS AND IMPORTANCE: Obscured IZ during early 
      stage GA was confirmed in a teenage patient with a chief complaint of blurred 
      vision. OCT is useful in the detection of minute morphological changes that occur 
      earlier in GA.
CI  - (c) 2022 The Authors.
FAU - Nitta, Keisuke
AU  - Nitta K
AD  - Department of Ophthalmology, Gunma University Graduate School of Medicine, 
      3-39-15 Showa-machi, Maebashi, Gunma, Japan.
FAU - Mukai, Ryo
AU  - Mukai R
AD  - Department of Ophthalmology, Gunma University Graduate School of Medicine, 
      3-39-15 Showa-machi, Maebashi, Gunma, Japan.
FAU - Akiyama, Hideo
AU  - Akiyama H
AD  - Department of Ophthalmology, Gunma University Graduate School of Medicine, 
      3-39-15 Showa-machi, Maebashi, Gunma, Japan.
LA  - eng
PT  - Case Reports
DEP - 20220120
PL  - United States
TA  - Am J Ophthalmol Case Rep
JT  - American journal of ophthalmology case reports
JID - 101679941
PMC - PMC8790631
OTO - NOTNLM
OT  - Gyrate atrophy of retina and choroid
OT  - Interdigitation zone
OT  - Multifocal electroretinogram
OT  - Optical coherence tomography
COIS- The authors declare no conflicts of interest, financial or otherwise.
EDAT- 2022/02/04 06:00
MHDA- 2022/02/04 06:01
PMCR- 2022/01/20
CRDT- 2022/02/03 05:36
PHST- 2020/05/27 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2022/01/13 00:00 [accepted]
PHST- 2022/02/03 05:36 [entrez]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/02/04 06:01 [medline]
PHST- 2022/01/20 00:00 [pmc-release]
AID - S2451-9936(22)00023-8 [pii]
AID - 101277 [pii]
AID - 10.1016/j.ajoc.2022.101277 [doi]
PST - epublish
SO  - Am J Ophthalmol Case Rep. 2022 Jan 20;25:101277. doi: 10.1016/j.ajoc.2022.101277. 
      eCollection 2022 Mar.