PMID- 35114394
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 254
DP  - 2022 Apr
TI  - Haloperidol alters the behavioral, hematological and biochemical parameters of 
      freshwater African catfish, Clarias gariepinus (Burchell 1822).
PG  - 109292
LID - S1532-0456(22)00027-8 [pii]
LID - 10.1016/j.cbpc.2022.109292 [doi]
AB  - The presence of drugs and their metabolites in surface waters and municipal 
      effluents has been reported in several studies, but their impacts on aquatic 
      organisms are not yet well studied. The present study investigated the effects of 
      exposure to the antipsychotic drug, haloperidol on the behavioral, hematological 
      and biochemical parameters in juvenile Clarias gariepinus. The fishes were 
      exposed to 0.12, 0.24 and 0.48 mg/L haloperidol for 15 days and later withdrawn 
      from the toxicant and allowed to recover for 5 days. Blood was sampled on days 1, 
      5, 10, 15, and after the 5-day recovery for hematological and biochemical 
      analysis. The pack cell volume (PCV), red blood cells (RBC), hemoglobin (Hb), 
      reticulocytes and lymphocyte counts were significantly reduced in the exposed 
      fish. The neutrophil counts were increased while that of monocytes, basophils and 
      eosinophils were not affected by the drug. The mean corpuscular volume (MCV), 
      mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration 
      (MCHC) were not different from the control on exposure to the drug. The 
      activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), 
      alkaline phosphatase (ALP), and acid phosphatase (ACP); and serum creatinine, 
      bile acid and bilirubin were increased on 15-day exposure to the drug. The 
      activity of the clotting factor fibrinogen was reduced compared to the control 
      after exposure to the drug. Haloperidol at concentrations used on 15-day exposure 
      were toxic to fish, but the effect appeared short-lived, as it dissipated on 
      5-day withdrawal from the drug. While further studies are needed to ascertain the 
      impact of prolonged exposure to environmentally relevant concentrations, caution 
      is advised to avoid eco-toxicological damage to aquatic organisms.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Chiejina, Chike Obinna
AU  - Chiejina CO
AD  - Department of Zoology and Environmental Biology, University of Nigeria Nsukka, 
      Enugu, Nigeria.
FAU - Anih, Lucy
AU  - Anih L
AD  - Department of Zoology and Environmental Biology, University of Nigeria Nsukka, 
      Enugu, Nigeria.
FAU - Okoye, Charles
AU  - Okoye C
AD  - Department of Zoology and Environmental Biology, University of Nigeria Nsukka, 
      Enugu, Nigeria.
FAU - Aguzie, Ifeanyi Oscar
AU  - Aguzie IO
AD  - Department of Zoology and Environmental Biology, University of Nigeria Nsukka, 
      Enugu, Nigeria.
FAU - Ali, Daoud
AU  - Ali D
AD  - Department of Zoology, College of Science, King Saud University, PO Box 2455, 
      Riyadh 11451, Saudi Arabia.
FAU - Kumar, Gokhlesh
AU  - Kumar G
AD  - Clinical Division of Fish Medicine, University of Veterinary Medicine Vienna, 
      1210 Vienna, Austria.
FAU - Nwani, Christopher Didigwu
AU  - Nwani CD
AD  - Department of Zoology and Environmental Biology, University of Nigeria Nsukka, 
      Enugu, Nigeria. Electronic address: chris.nwani@unn.edu.ng.
LA  - eng
PT  - Journal Article
DEP - 20220131
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Water Pollutants, Chemical)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - *Catfishes
MH  - Erythrocyte Indices
MH  - Fresh Water
MH  - Haloperidol/toxicity
MH  - *Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Biochemical parameters
OT  - Clotting factor
OT  - Fish
OT  - Haloperidol
OT  - Hematology
EDAT- 2022/02/04 06:00
MHDA- 2022/04/05 06:00
CRDT- 2022/02/03 20:13
PHST- 2021/11/13 00:00 [received]
PHST- 2022/01/20 00:00 [revised]
PHST- 2022/01/26 00:00 [accepted]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/02/03 20:13 [entrez]
AID - S1532-0456(22)00027-8 [pii]
AID - 10.1016/j.cbpc.2022.109292 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2022 Apr;254:109292. doi: 
      10.1016/j.cbpc.2022.109292. Epub 2022 Jan 31.