PMID- 35114442
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20240109
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 105
DP  - 2022 Apr
TI  - Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of 
      cellular basophils activation and passive cutaneous anaphylaxis in mice.
PG  - 108567
LID - S1567-5769(22)00051-0 [pii]
LID - 10.1016/j.intimp.2022.108567 [doi]
AB  - Basophils and mast cells are characteristic effector cells in allergic reactions. 
      Sargahydorquinoic acid (SHQA), a compound isolated from Sargassum serratifolium 
      (marine alga), possesses various biochemical properties, including potent 
      antioxidant activities. The objective of the present study was to investigate 
      inhibitory effects of SHQA on the activation of human basophilic KU812F cells 
      induced by phorbol myristate acetate and A23187 (PMACI), a calcium ionophore. 
      Furthermore, we confirmed the inhibitory effects of SHQA on the activation of rat 
      basophilic leukemia (RBL)-2H3 cells induced by compound 48/80 (com 48/80), bone 
      marrow-derived mast cells (BMCMCs) induced by 
      anti-dinitrophenyl(DNP)-immunoglobulin E (IgE)/DNP-bovine serum albumin (BSA), 
      DNP/IgE and on the reaction of passive cutaneous anaphylaxis (PCA) mediated by 
      IgE. SHQA reduced PMACI-induced intracellular reactive oxygen species (ROS) and 
      calcium levels. Western blot analysis revealed that SHQA downregulated the 
      activation of ERK, p38, and NF-kappaB in a dose-dependent manner. Moreover, SHQA 
      suppressed the production and gene expression of various cytokines, including 
      interleukin (IL)-1 beta, IL-4, IL-6, and IL-8 in PMACI-induced KU812F cells and IL-4 
      and tumor necrosis factor (TNF)- alpha in com 48/80-induced RBL-2H3 cells. It also 
      determined the inhibition of PMACI, com 48/80- and IgE/DNP-induced degranulation 
      by reducing the release of beta -hexosaminidase. Furthermore, it attenuated the 
      IgE/DNP-induced PCA reaction in the ears of BALB/c mice. These results suggest 
      that SHQA isolated from S. serratifolium is a potential therapeutic functional 
      food material for inhibiting effector cell activation in allergic reactions and 
      anaphylaxis in animal model.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Seong Choi, Kap
AU  - Seong Choi K
AD  - Department of Food Science and Biotechnology, Sunchon National University, 
      Suncheon 57922, Republic of Korea.
FAU - Shin, Tai-Sun
AU  - Shin TS
AD  - Division of Food and Nutrition, Chonnam National University, Gwangju 61186, 
      Republic of Korea.
FAU - Chun, Jiyeon
AU  - Chun J
AD  - Department of Food Science and Biotechnology, Sunchon National University, 
      Suncheon 57922, Republic of Korea.
FAU - Ahn, Ginnae
AU  - Ahn G
AD  - Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, 
      Republic of Korea.
FAU - Jeong Han, Eui
AU  - Jeong Han E
AD  - Research Center for Healthcare and Biomedical Engineering, Chonnam National 
      University, Yeosu 59626, Korea; Department of Food Technology and Nutrition, 
      Chonnam National University, Yeosu 59626, Republic of Korea.
FAU - Kim, Min-Jong
AU  - Kim MJ
AD  - Cell & Matrix Research Institute, Department of Pharmacology, Kyungpook National 
      University School of Medicine, Daegu, Republic of Korea.
FAU - Kim, Jung-Beom
AU  - Kim JB
AD  - Department of Food Science and Biotechnology, Sunchon National University, 
      Suncheon 57922, Republic of Korea.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Cell & Matrix Research Institute, Department of Pharmacology, Kyungpook National 
      University School of Medicine, Daegu, Republic of Korea.
FAU - Kho, Kang-Hee
AU  - Kho KH
AD  - Department of Fisheries Science, College of Fisheries and Ocean Sciences, Chonnam 
      National University, Yeosu 59626, Republic of Korea.
FAU - Heon Kim, Dae
AU  - Heon Kim D
AD  - Department of Biology, Sunchon National University, Suncheon 57922, Republic of 
      Korea.
FAU - Shim, Sun-Yup
AU  - Shim SY
AD  - Department of Food Science and Biotechnology, Sunchon National University, 
      Suncheon 57922, Republic of Korea. Electronic address: shimsy@scnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220201
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Alkenes)
RN  - 0 (Benzoquinones)
RN  - 0 (sargahydroquinoic acid)
SB  - IM
MH  - Alkenes
MH  - *Anaphylaxis/metabolism
MH  - Animals
MH  - Basophils
MH  - Benzoquinones
MH  - Mast Cells
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis
MH  - Rats
MH  - *Sargassum
OTO - NOTNLM
OT  - Basophils
OT  - Cytokines
OT  - Degranulation
OT  - Passive cutaneous anaphylaxis
OT  - Sargahydroquinoic acid
OT  - Sargassum serratifolium
EDAT- 2022/02/04 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/02/03 20:14
PHST- 2021/07/15 00:00 [received]
PHST- 2022/01/10 00:00 [revised]
PHST- 2022/01/20 00:00 [accepted]
PHST- 2022/02/04 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/02/03 20:14 [entrez]
AID - S1567-5769(22)00051-0 [pii]
AID - 10.1016/j.intimp.2022.108567 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2022 Apr;105:108567. doi: 10.1016/j.intimp.2022.108567. Epub 
      2022 Feb 1.