PMID- 35114775
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220531
IS  - 1509-572X (Electronic)
IS  - 1509-572X (Linking)
VI  - 59
IP  - 4
DP  - 2021
TI  - Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative 
      for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial 
      neoplasms?
PG  - 350-358
LID - 46159 [pii]
LID - 10.5114/fn.2021.112562 [doi]
AB  - AIM OF THE STUDY: Oligodendrocyte transcriptional factor-2 (Olig2) is an 
      essential marker for oligodendrocytes expression. We aimed to explore the 
      expression of Olig2 in different glial neoplasms and to investigate if diffuse 
      Olig2 expression can replace 1p19q co-deletion for the diagnosis of 
      oligodendroglioma. MATERIAL AND METHODS: Olig2 was performed on 53 samples of 
      different glial neoplasms using immunohistochemistry (IHC). 1p/19q deletions were 
      investigated using fluorescence in situ hybridization (FISH). RESULTS: Olig2 
      labelling of different glial neoplasms revealed various expressions, in which 26 
      tumours showed diffuse expression (>/= 60%) and 23 tumours showed partial focal 
      expression (< 50%). Four tumours showed no expression. Of the 26 tumours, 6 
      oligodendrogliomas had 1p19q co-deletion and the remaining 3 oligodendrogliomas 
      showed no co-deletion. Three non-oligodendroglial tumours were found to have 19q 
      deletion. The FISH of the remaining tumours (14/26) showed no aberrations. There 
      was no significant difference in the final diagnosis by using 1p19q co-deletion 
      test among glial neoplasms with diffuse Olig2 expression (p = 0.248). 
      CONCLUSIONS: Olig2 marker cannot be used as an alternative diagnostic method for 
      1p19q co-deletion to distinguish oligodendrogliomas from other glial neoplasms. 
      Although some glial tumours showed diffuse Olig2 expression, 1p19q co-deletion 
      testing is the best diagnostic method.
FAU - Kurdi, Maher
AU  - Kurdi M
AD  - Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz 
      University, Saudi Arabia.
FAU - Alkhatabi, Heba
AU  - Alkhatabi H
AD  - Department of Medical Laboratory Technology, Faculty of Applied Medical Science, 
      King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Butt, Nadeem
AU  - Butt N
AD  - Department of Family and Community Medicine, Faculty of Medicine in Rabigh, King 
      Abdulaziz University, Saudi Arabia.
FAU - Albayjani, Hameedah
AU  - Albayjani H
AD  - Center of Excellence in Genomic Research, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Aljhdali, Hessa
AU  - Aljhdali H
AD  - Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Mohamed, Fawaz
AU  - Mohamed F
AD  - Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz 
      University, Saudi Arabia.
FAU - Alsinani, Taghreed
AU  - Alsinani T
AD  - Department of Surgery, King Fahad General Hospital, Jeddah, Saudi Arabia.
FAU - Baeesa, Saleh
AU  - Baeesa S
AD  - Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Almuhaini, Eman
AU  - Almuhaini E
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia.
FAU - Al-Ghafari, Ayat
AU  - Al-Ghafari A
AD  - Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz 
      University, Jeddah, Saudi Arabia.
FAU - Hakamy, Sahar
AU  - Hakamy S
AD  - Center of Excellence in Genomic Research, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Faizo, Eyad
AU  - Faizo E
AD  - Department of Neurosurgery, Tabuk University, Tabuk, Saudi Arabia.
FAU - Bahakeem, Basem
AU  - Bahakeem B
AD  - Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
RN  - 0 (OLIG2 protein, human)
RN  - 0 (Oligodendrocyte Transcription Factor 2)
SB  - IM
MH  - *Brain Neoplasms/diagnosis/genetics
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 19/genetics
MH  - *Glioma/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Oligodendrocyte Transcription Factor 2/*genetics
MH  - Oligodendroglia
MH  - *Oligodendroglioma/diagnosis/genetics
OTO - NOTNLM
OT  - 1p19q co-deletion
OT  - FISH
OT  - Olig2
OT  - oligodendroglioma
OT  - gliomas
EDAT- 2022/02/05 06:00
MHDA- 2022/02/08 06:00
CRDT- 2022/02/04 02:15
PHST- 2022/02/04 02:15 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
AID - 46159 [pii]
AID - 10.5114/fn.2021.112562 [doi]
PST - ppublish
SO  - Folia Neuropathol. 2021;59(4):350-358. doi: 10.5114/fn.2021.112562.