PMID- 35114883 OWN - NLM STAT- MEDLINE DCOM- 20220330 LR - 20220501 IS - 1651-226X (Electronic) IS - 0284-186X (Linking) VI - 61 IP - 4 DP - 2022 Apr TI - The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study. PG - 449-458 LID - 10.1080/0284186X.2022.2033830 [doi] AB - BACKGROUND: This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (n = 1808). Kaplan-Meier curves and multivariable Cox regression analyses were performed to compare the survival of patients with different smoking history. Interactions between ATE and (A) tumor subsite and (B) excessive alcohol consumption (EAC) on the survival were evaluated using multivariable Cox regression analyses with interaction terms. RESULTS: We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57-71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%-57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (0 < x 60 PYs), however only for DFS of patients with >60 PYs, compared to 0 PYs. Furthermore, an unfavorable long-term prognosis was evident after >3.5 (OS) and >2.5 (DFS) years from diagnosis for patients who continued smoking compared to patients with smoking cessation at diagnosis. The survival estimates of patients with different tumor subsite and alcohol consumption differed with increasing ATE. CONCLUSION: Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption. FAU - Andersen, Amanda Oester AU - Andersen AO AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Jensen, Jakob Schmidt AU - Jensen JS AUID- ORCID: 0000-0002-6636-6924 AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Jakobsen, Kathrine Kronberg AU - Jakobsen KK AUID- ORCID: 0000-0003-0336-5411 AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Stampe, Helene AU - Stampe H AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Nielsen, Kristoffer Juul AU - Nielsen KJ AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Wessel, Irene AU - Wessel I AUID- ORCID: 0000-0001-9986-5001 AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Christensen, Anders AU - Christensen A AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Andersen, Elo AU - Andersen E AUID- ORCID: 0000-0002-2476-1037 AD - Department of Oncology, Herlev-Gentofte University Hospital, Capital Region, Denmark. FAU - Friborg, Jeppe AU - Friborg J AUID- ORCID: 0000-0001-5423-0627 AD - Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Gronhoj, Christian AU - Gronhoj C AUID- ORCID: 0000-0002-4524-8291 AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - von Buchwald, Christian AU - von Buchwald C AUID- ORCID: 0000-0001-6753-8129 AD - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20220204 PL - Sweden TA - Acta Oncol JT - Acta oncologica (Stockholm, Sweden) JID - 8709065 SB - IM MH - *Carcinoma, Squamous Cell/epidemiology/etiology MH - Disease-Free Survival MH - Female MH - *Head and Neck Neoplasms MH - Humans MH - Male MH - Middle Aged MH - *Mouth Neoplasms/epidemiology/etiology MH - Prognosis MH - Retrospective Studies MH - Squamous Cell Carcinoma of Head and Neck MH - Tobacco Smoking/adverse effects/epidemiology OTO - NOTNLM OT - Cox regression analyses OT - Oral squamous cell carcinoma OT - accumulated tobacco exposure OT - packyears OT - restricted cubic spline OT - tobacco smoking EDAT- 2022/02/05 06:00 MHDA- 2022/03/31 06:00 CRDT- 2022/02/04 05:35 PHST- 2022/02/05 06:00 [pubmed] PHST- 2022/03/31 06:00 [medline] PHST- 2022/02/04 05:35 [entrez] AID - 10.1080/0284186X.2022.2033830 [doi] PST - ppublish SO - Acta Oncol. 2022 Apr;61(4):449-458. doi: 10.1080/0284186X.2022.2033830. Epub 2022 Feb 4.