PMID- 35115003
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Feb 3
TI  - The effect of periodic ketogenic diet on newly diagnosed overweight or obese 
      patients with type 2 diabetes.
PG  - 34
LID - 10.1186/s12902-022-00947-2 [doi]
LID - 34
AB  - BACKGROUND: The ketogenic diet (KD) is characterized by fat as a substitute of 
      carbohydrates for the primary energy source. There is a large number of 
      overweight or obese people with type 2 diabetes mellitus (T2DM), while this study 
      aims to observe periodic ketogenic diet for effect on overweight or obese 
      patients newly diagnosed as T2DM. METHODS: A total of 60 overweight or obese 
      patients newly diagnosed as T2DM were randomized into two groups: KD group, which 
      was given ketogenic diet, and control group, which was given routine diet for 
      diabetes, 30 cases in each group. Both dietary patterns lasted 12 weeks, and 
      during the period, the blood glucose, blood lipid, body weight, insulin, and uric 
      acid before and after intervention, as well as the significance for relevant 
      changes, were observed. RESULTS: For both groups, the weight, BMI(body mass 
      index), Waist, TG (triglyceride), TC(cholesterol), LDL (low-density lipoprotein 
      cholesterol), HDL (high-density lipoprotein cholesterol), FBG (fasting glucose), 
      FINS (fasting insulin), HbA1c (glycosylated hemoglobin) were decreased after 
      intervention (P < 0.05), while the decrease rates in the KD group was more 
      significant than the control group. However, UA(serum uric acid) in the KD group 
      showed an upward trend, while in the control group was not changed significantly 
      (P > 0.05).The willingness to adhere to the ketogenic diet over the long term was 
      weaker than to the routine diet for diabetes. CONCLUSION: Among the overweight or 
      obese patients newly diagnosed as type 2 diabetes mellitus, periodic ketogenic 
      diet can not only control the body weight, but also control blood glucose and 
      lipid, but long-term persistence is difficult.
CI  - (c) 2022. The Author(s).
FAU - Li, Sumei
AU  - Li S
AUID- ORCID: 0000-0002-6963-5309
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China. 
      ptsyy.lsm@163.com.
FAU - Lin, Guoxin
AU  - Lin G
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
FAU - Chen, Jinxing
AU  - Chen J
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
FAU - Chen, Zhenxin
AU  - Chen Z
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
FAU - Xu, Feipeng
AU  - Xu F
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
FAU - Zhu, Feng
AU  - Zhu F
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
FAU - Zhang, Jintian
AU  - Zhang J
AD  - Department of Pathology, Putian University, Medical University, Fujian, China.
FAU - Yuan, Shouping
AU  - Yuan S
AD  - Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, 
      Fujian Medical University, Putian, Fujian Province, People's Republic of China.
LA  - eng
GR  - 2020SY002/Putian Science and Technology Bureau/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220203
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*diet therapy
MH  - *Diet, Ketogenic
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/*diet therapy
MH  - Overweight/*diet therapy
PMC - PMC8811985
OTO - NOTNLM
OT  - Being overweight. Type 2 diabetes
OT  - Ketogenic diet
OT  - Newly diagnosis
OT  - Obesity
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/05 06:00
MHDA- 2022/03/19 06:00
PMCR- 2022/02/03
CRDT- 2022/02/04 05:35
PHST- 2020/06/15 00:00 [received]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/02/04 05:35 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2022/02/03 00:00 [pmc-release]
AID - 10.1186/s12902-022-00947-2 [pii]
AID - 947 [pii]
AID - 10.1186/s12902-022-00947-2 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Feb 3;22(1):34. doi: 10.1186/s12902-022-00947-2.