PMID- 35115410
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20231115
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 9
IP  - 2
DP  - 2022 Mar
TI  - Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional 
      to DRB1*07:01 in Anti-LGI1 Encephalitis.
LID - 10.1212/NXI.0000000000001140 [doi]
LID - e1140
AB  - BACKGROUND AND OBJECTIVES: To study human leukocyte antigen (HLA) allele 
      associations in anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis. 
      METHODS: A multiethnic cohort of 269 patients with anti-LGI1 encephalitis and 
      1,359 controls was included. Four-digit HLA sequencing and genome wide 
      association single-nucleotide polymorphism typing imputation (0.99 concordance) 
      were used for HLA typing. Significance of primary and secondary associations was 
      tested using chi(2), Fisher exact tests, or logistic regression with the control of 
      population stratification covariates when applicable. RESULTS: DRB1*07:01 and 
      DQA1*02:01, 2 alleles in strong linkage disequilibrium, were associated with the 
      disease (90% vs 24%, OR = 27.8, p < 10e(-50)) across ethnicity independent of 
      variation at DRB3 and DQB1, 2 flanking HLA loci. DRB1*07:01 homozygosity was 
      associated with a doubling of risk (OR = 2.1, p = 0.010), suggesting causality. 
      DRB1*07:01 negative subjects were younger (p = 0.003) and more frequently female 
      (p = 0.015). Three patients with malignant thymomas did not carry DRB1*07:01, 
      whereas patients with other tumors had high DRB1*07:01 frequency, suggesting that 
      the presence of tumors other than thymomas may be coincidental and not causal. In 
      both DRB1*07:01 heterozygous individuals and DRB1*07:01 negative subjects, 
      DRB1*04:02 was associated with anti-LGI1 encephalitis, indicating an independent 
      effect of this allele (OR = 6.85, p = 4.57 x 10(-6) and OR = 8.93, p = 2.50 x 
      10(-3), respectively). DRB1*04:02 was also independently associated with younger 
      age at onset (beta = -6.68, p = 9.78 x 10(-3)). Major histocompatibility complex 
      peptide-binding predictions using LGI1-derived peptides revealed divergent 
      binding propensities for DRB1*04:02 and DRB1*07:01 alleles, suggesting 
      independent pathogenic mechanisms. DISCUSSION: In addition to the established 
      primary DRB1*07:01 association in anti-LGI1 encephalitis, we observe a secondary 
      effect of DRB1*04:02 with lower age at onset. Our study provides evidence for 
      secondary effects within HLA locus that correlate with clinical phenotypes in 
      anti-LGI1 encephalitis.
CI  - Copyright (c) 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Peris Sempere, Vicente
AU  - Peris Sempere V
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Muniz-Castrillo, Sergio
AU  - Muniz-Castrillo S
AUID- ORCID: 0000-0001-5958-3288
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Ambati, Aditya
AU  - Ambati A
AUID- ORCID: 0000-0001-8462-3552
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Binks, Sophie
AU  - Binks S
AUID- ORCID: 0000-0003-0991-5998
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Pinto, Anne-Laurie
AU  - Pinto AL
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Rogemond, Veronique
AU  - Rogemond V
AUID- ORCID: 0000-0003-2098-920X
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Pittock, Sean J
AU  - Pittock SJ
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Dubey, Divyanshu
AU  - Dubey D
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Geschwind, Michael D
AU  - Geschwind MD
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Gelfand, Jeffrey Marc
AU  - Gelfand JM
AUID- ORCID: 0000-0002-5121-3319
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Dilwali, Sonam
AU  - Dilwali S
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Lee, Soon-Tae
AU  - Lee ST
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Knight, Julian
AU  - Knight J
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Elliott, Katherine S
AU  - Elliott KS
AUID- ORCID: 0000-0002-8125-797X
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Irani, Sarosh
AU  - Irani S
AUID- ORCID: 0000-0002-7667-9748
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Honnorat, Jerome
AU  - Honnorat J
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom.
FAU - Mignot, Emmanuel
AU  - Mignot E
AUID- ORCID: 0000-0002-6928-5310
AD  - From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), 
      Stanford University School of Medicine, Palo Alto, CA; French Reference Center 
      for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., 
      A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hopital Neurologique; Synatac 
      Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM 
      U1217/CNRS UMR5310, Universite Claude Bernard Lyon 1, Universite de Lyon, France; 
      Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of 
      Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and 
      S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory 
      Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and 
      D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and 
      S.D.), University of California, San Francisco; Department of Neurology 
      (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre 
      for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University 
      of Oxford, United Kingdom. mignot@stanford.edu.
LA  - eng
GR  - MR/V007173/1/MRC_/Medical Research Council/United Kingdom
GR  - U01 AI125250/AI/NIAID NIH HHS/United States
GR  - 104079/Z/14/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220203
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - 0 (anti-leucine-rich glioma-inactivated 1 autoantibody)
SB  - IM
MH  - Aged
MH  - Autoantibodies
MH  - *Autoimmune Diseases of the Nervous System/genetics/immunology
MH  - *Encephalitis/genetics/immunology
MH  - Female
MH  - Genetic Association Studies
MH  - *Genome-Wide Association Study
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC8815287
EDAT- 2022/02/05 06:00
MHDA- 2022/03/15 06:00
PMCR- 2022/02/03
CRDT- 2022/02/04 05:44
PHST- 2021/08/23 00:00 [received]
PHST- 2021/12/27 00:00 [accepted]
PHST- 2022/02/04 05:44 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/02/03 00:00 [pmc-release]
AID - 9/2/e1140 [pii]
AID - NEURIMMINFL2021039395 [pii]
AID - 10.1212/NXI.0000000000001140 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2022 Feb 3;9(2):e1140. doi: 
      10.1212/NXI.0000000000001140. Print 2022 Mar.