PMID- 35116128
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1976-1457 (Print)
IS  - 2005-6168 (Electronic)
IS  - 1976-1457 (Linking)
VI  - 16
IP  - 1
DP  - 2022 Feb
TI  - The efficacy and safety of Dendropanax morbifera leaf extract on the metabolic 
      syndrome: a 12-week, placebo controlled, double blind, and randomized controlled 
      trial.
PG  - 60-73
LID - 10.4162/nrp.2022.16.1.60 [doi]
AB  - BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse 
      therapeutic potentials. We aimed to evaluate the efficacy and safety of D. 
      morbifera leaf extract for improving metabolic parameters in human. 
      SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized 
      trial included a total of 74 adults, and they were assigned to the placebo group 
      (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints 
      were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in 
      addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS 
      components. Safety was assessed by monitoring adverse events (AEs). RESULTS: 
      After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly 
      decreased in the D. morbifera group compared to that of the placebo group 
      (difference: -0.13 +/- 0.20% vs. 0.00 +/- 0.28%, P = 0.031; % of change: -2.27 +/- 
      3.63% vs. 0.10 +/- 5.10%, P = 0.025). The homeostatic model assessment for insulin 
      resistance level also decreased significantly from its baseline in the D. 
      morbifera group. The systolic BP of D. morbifera group decreased significantly 
      than that of placebo group (difference: -3.9 +/- 9.8 mmHg vs. 3.3 +/- 11.7 mmHg, P = 
      0.005; % of change: -2.8 +/- 7.7% vs. 3.3 +/- 10.2%, P = 0.005). However, the lipid 
      parameters and body composition including body weight did not differ between the 
      groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of 
      MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. 
      morbifera group than it was in the placebo group. No serious AEs occurred in 
      either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 
      12-week period improved metabolic parameters such as HbA1c and BP and reduced the 
      prevalence of MetS. TRIAL REGISTRATION: Clinical Research Information Service 
      Identifier: KCT0004672.
CI  - (c)2022 The Korean Nutrition Society and the Korean Society of Community Nutrition.
FAU - Jun, Ji Eun
AU  - Jun JE
AUID- ORCID: 0000-0002-7204-4913
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
FAU - Hwang, You-Cheol
AU  - Hwang YC
AUID- ORCID: 0000-0003-4033-7874
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
AUID- ORCID: 0000-0002-4648-3605
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
FAU - Chung, Ho Yeon
AU  - Chung HY
AUID- ORCID: 0000-0002-4529-8280
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
FAU - Choung, Se Young
AU  - Choung SY
AUID- ORCID: 0000-0001-7619-6263
AD  - Department of Preventive Pharmacy and Toxicology, Department of Life and 
      Nanopharmaceutical Sciences of Pharmacy, College of Pharmacy, Kyung Hee 
      University, Seoul 02447, Korea.
FAU - Jeong, In-Kyung
AU  - Jeong IK
AUID- ORCID: 0000-0001-7857-546X
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210629
PL  - Korea (South)
TA  - Nutr Res Pract
JT  - Nutrition research and practice
JID - 101311052
PMC - PMC8784258
OTO - NOTNLM
OT  - Metabolic syndrome
OT  - functional food
OT  - glucose
OT  - hypertension
COIS- Conflict of Interest: The authors declare no potential conflicts of interests.
EDAT- 2022/02/05 06:00
MHDA- 2022/02/05 06:01
PMCR- 2022/02/01
CRDT- 2022/02/04 05:48
PHST- 2021/01/21 00:00 [received]
PHST- 2021/04/08 00:00 [revised]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2022/02/04 05:48 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/02/05 06:01 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 10.4162/nrp.2022.16.1.60 [doi]
PST - ppublish
SO  - Nutr Res Pract. 2022 Feb;16(1):60-73. doi: 10.4162/nrp.2022.16.1.60. Epub 2021 
      Jun 29.