PMID- 35116132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220205
IS  - 1976-1457 (Print)
IS  - 2005-6168 (Electronic)
IS  - 1976-1457 (Linking)
VI  - 16
IP  - 1
DP  - 2022 Feb
TI  - High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal 
      range, is associated with gestational diabetes mellitus: a prospective cohort 
      study.
PG  - 120-131
LID - 10.4162/nrp.2022.16.1.120 [doi]
AB  - BACKGROUND/OBJECTIVES: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) 
      levels can increase gestational diabetes mellitus (GDM) risk, although 
      inconsistent findings related to that association have been reported. This study 
      examined the association of serum vitamin D with GDM and the possible influencers 
      on this association. SUBJECTS/METHODS: This study included 259 pregnant women 
      within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of 
      gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 
      24 to 32 weeks of gestation using a standard procedure. Association between serum 
      vitamin D and GDM was tested using binary logistic regression. RESULTS: Nearly 
      all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). 
      Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than 
      GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy 
      serum vitamin D levels had a greater risk of GDM. However, this significant 
      association was only identified among those with a family history of type 2 
      diabetes mellitus (T2DM) and in women with a body mass index indicating 
      overweight or obese status. CONCLUSIONS: The high prevalence of VDD in this 
      sample of pregnant women underscores the need for effective preventive public 
      health strategies. Further investigation of this unexpected association between 
      serum vitamin D level and GDM risk in predominantly VDD pregnant women and the 
      potential effects of adiposity and family history of T2DM on that association is 
      warranted.
CI  - (c)2022 The Korean Nutrition Society and the Korean Society of Community Nutrition.
FAU - Yong, Heng Yaw
AU  - Yong HY
AUID- ORCID: 0000-0002-0454-641X
AD  - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Mohd Shariff, Zalilah
AU  - Mohd Shariff Z
AUID- ORCID: 0000-0002-5347-4627
AD  - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Palaniveloo, Lalitha
AU  - Palaniveloo L
AUID- ORCID: 0000-0002-0321-4229
AD  - Center for Nutrition Epidemiology Research, Institute for Public Health, National 
      Institute of Health, Ministry of Health, 40170 Selangor, Malaysia.
FAU - Loh, Su Peng
AU  - Loh SP
AUID- ORCID: 0000-0002-5609-8065
AD  - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Mohd Yusof, Barakatun Nisak
AU  - Mohd Yusof BN
AUID- ORCID: 0000-0003-0403-5895
AD  - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Rejali, Zulida
AU  - Rejali Z
AUID- ORCID: 0000-0002-1386-5527
AD  - Department of Obstetrics and Gynaecology, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Bindels, Jacques
AU  - Bindels J
AUID- ORCID: 0000-0001-7937-7107
AD  - Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.
FAU - Tee, Yvonne Yee Siang
AU  - Tee YYS
AUID- ORCID: 0000-0001-7129-5764
AD  - Danone Specialized Nutrition (Malaysia), 59200 Kuala Lumpur, Malaysia.
FAU - van der Beek, Eline M
AU  - van der Beek EM
AUID- ORCID: 0000-0002-7923-3653
AD  - Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.
AD  - Department of Pediatrics, University Medical Centre Groningen, University of 
      Groningen, 9712 CP Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210812
PL  - Korea (South)
TA  - Nutr Res Pract
JT  - Nutrition research and practice
JID - 101311052
PMC - PMC8784260
OTO - NOTNLM
OT  - Vitamin D
OT  - body mass index
OT  - gestational diabetes mellitus
OT  - vitamin D deficiency
COIS- Conflict of Interest: Yvonne Yee Siang Tee and Jacques Bindels are employees of 
      Danone Specialized Nutrition (Malaysia) and of Nutricia Research Foundation 
      (Netherlands), respectively. Eline van der Beek was employed by Danone Nutricia 
      Research at the time of the study was conducted (former employee). None of the 
      authors had any personal or financial conflict of interest.
EDAT- 2022/02/05 06:00
MHDA- 2022/02/05 06:01
PMCR- 2022/02/01
CRDT- 2022/02/04 05:48
PHST- 2020/08/07 00:00 [received]
PHST- 2021/02/22 00:00 [revised]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2022/02/04 05:48 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/02/05 06:01 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 10.4162/nrp.2022.16.1.120 [doi]
PST - ppublish
SO  - Nutr Res Pract. 2022 Feb;16(1):120-131. doi: 10.4162/nrp.2022.16.1.120. Epub 2021 
      Aug 12.