PMID- 35116371
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2219-6803 (Electronic)
IS  - 2218-676X (Print)
IS  - 2218-676X (Linking)
VI  - 10
IP  - 12
DP  - 2021 Dec
TI  - Relationship between Kita-Kyushu Lung Cancer antigen-1 expression and prognosis 
      of cases with lung squamous cell carcinoma.
PG  - 5212-5221
LID - 10.21037/tcr-21-1581 [doi]
AB  - BACKGROUND: Previously, we identified the highly immunogenic cancer testicular 
      antigen named Kita-Kyushu Lung Cancer antigen-1 (KK-LC-1). In this study, we 
      analyzed the effect of KK-LC-1 expression on the prognosis of patients with 
      resected squamous cell lung cancer. METHODS: Fifty squamous cell lung cancer 
      patients, who received complete resection, were enrolled in this study. The 
      expressions of KK-LC-1, CD8, human leukocyte antigen (HLA) class I, and 
      programmed cell death protein ligand-1 (PD-L1) were assessed via 
      immunohistochemistry staining using the specimens obtained from the participants. 
      The association between the expression of the abovementioned molecules and 
      patient prognosis was investigated. RESULTS: KK-LC-1 expression was observed in 
      21 of 50 recruited cases (42%). However, no significant correlation was found 
      between KK-LC-1 expression and patient prognosis. The prognosis was significantly 
      better in lung cancer cases with KK-LC-1 expression in which CD8(+) T cells 
      infiltrated the tumor. Regardless of the HLA class I expression or the PD-L1 
      expression, the KK-LC-1 expression in squamous cell lung cancer could not be 
      detected as a significant prognostic factor. Furthermore, considering the 
      polarity of the cancer tissue as epithelium, staining of KK-LC-1 tended to be 
      strong in the area corresponding to the basal side of the tumor tissue. The Ki-67 
      expression was frequently observed in cancer cells on the basal side, which was 
      consistent with the KK-LC-1 expression in representative four cases with 
      KK-LC-1-positive squamous cell lung cancer. CONCLUSIONS: Our results indicated 
      that lung squamous cell cancer patients with KK-LC-1 expression and the tumor 
      infiltrating CD8(+) T cells might exhibit better prognosis. KK-LC-1 might be 
      highly expressed in cancer cells with high proliferative capacity. Larger cohort 
      analysis is still required for further elucidation and validation of the results 
      of this study.
CI  - 2021 Translational Cancer Research. All rights reserved.
FAU - Ichiki, Yoshinobu
AU  - Ichiki Y
AD  - Department of General Thoracic Surgery, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
AD  - Second Department of Surgery, University of Occupational and Environmental 
      Health, School of Medicine, Kitakyushu, Japan.
FAU - Fukuyama, Takashi
AU  - Fukuyama T
AD  - Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, 
      Japan.
FAU - Ohmiya, Haruki
AU  - Ohmiya H
AD  - Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, 
      Japan.
FAU - Ueno, Mari
AU  - Ueno M
AD  - Department of Diagnostic Pathology, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Yanagi, Shinya
AU  - Yanagi S
AD  - Department of Diagnostic Pathology, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Kanasaki, Yoshiro
AU  - Kanasaki Y
AD  - Department of General Thoracic Surgery, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Goto, Hidenori
AU  - Goto H
AD  - Department of General Thoracic Surgery, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Mikami, Shuji
AU  - Mikami S
AD  - Department of Diagnostic Pathology, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Yamazaki, Hitoshi
AU  - Yamazaki H
AD  - Division of Pathology, Kitasato University Medical Center, Kitamoto, Japan.
FAU - Nakanishi, Kozo
AU  - Nakanishi K
AD  - Department of General Thoracic Surgery, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
FAU - Ishida, Tsuyoshi
AU  - Ishida T
AD  - Department of Diagnostic Pathology, National Hospital Organization, Saitama 
      Hospital, Wako, Japan.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Cancer Res
JT  - Translational cancer research
JID - 101585958
PMC - PMC8798488
OTO - NOTNLM
OT  - Kita-Kyushu Lung Cancer antigen-1 (KK-LC-1)
OT  - Lung cancer
OT  - cytotoxic T lymphocyte (CTL)
OT  - programmed cell death protein ligand-1 (PD-L1)
OT  - tumor immunology
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at https://dx.doi.org/10.21037/tcr-21-1581). The authors have no 
      conflicts of interest to declare.
EDAT- 2022/02/05 06:00
MHDA- 2022/02/05 06:01
PMCR- 2021/12/01
CRDT- 2022/02/04 05:48
PHST- 2021/08/09 00:00 [received]
PHST- 2021/11/04 00:00 [accepted]
PHST- 2022/02/04 05:48 [entrez]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2022/02/05 06:01 [medline]
PHST- 2021/12/01 00:00 [pmc-release]
AID - tcr-10-12-5212 [pii]
AID - 10.21037/tcr-21-1581 [doi]
PST - ppublish
SO  - Transl Cancer Res. 2021 Dec;10(12):5212-5221. doi: 10.21037/tcr-21-1581.