PMID- 35117165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2219-6803 (Electronic)
IS  - 2218-676X (Print)
IS  - 2218-676X (Linking)
VI  - 9
IP  - 1
DP  - 2020 Jan
TI  - The prognostic value of tumor budding in laryngeal squamous cell carcinoma.
PG  - 119-127
LID - 10.21037/tcr.2019.11.28 [doi]
AB  - BACKGROUND: The predictive value of tumor budding in several cancers is of the 
      essence. The 5-year survival of laryngeal squamous cell carcinoma patients is 
      decreasing despite the improvement of therapy. In order to help improve the 
      prognosis of LSCC patients, we aimed to investigate the value of tumor budding on 
      the prognosis in laryngeal squamous cell cancer (LSCC) by the pathological 
      characteristics of the surgical cases. METHODS: Archival clinical specimens of 51 
      patients diagnosed with LSCC were included in the research. On the basis of 
      hematoxylin and eosin (H&E)-stained slides, tumor-stroma ratio (TSR), tumor 
      budding and nuclear features were assessed. Correlation between clinical data and 
      histologic characteristics was carried out using the Kaplan-Meier method and the 
      Cox proportional hazards regression model, respectively. RESULTS: Total tumor 
      budding was independent prognostic parameter of 5-year recurrence-free survival 
      (RFS) and overall survival (OS) in LSCC. The evaluation of tumor budding can be 
      as a part of the routine histopathological report in LSCC. CONCLUSIONS: Tumor 
      budding can be an independent factor of prognosis of LSCC patients and should be 
      as a part of routine histopathologic report for LSCC cases.
CI  - 2020 Translational Cancer Research. All rights reserved.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Pathology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai 200025, China.
AD  - Department of Pathology, The First Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou 510120, China.
FAU - Sheng, Xiaoli
AU  - Sheng X
AD  - Department of Otorhinolaryngology, Guangdong Provincial People's Hospital & 
      Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Zhang, Siyi
AU  - Zhang S
AD  - Department of Otorhinolaryngology, Guangdong Provincial People's Hospital & 
      Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Gu, Xia
AU  - Gu X
AD  - Department of Pathology, The First Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou 510120, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Cancer Res
JT  - Translational cancer research
JID - 101585958
PMC - PMC8799290
OTO - NOTNLM
OT  - Prognostic
OT  - laryngeal
OT  - squamous cell cancer
OT  - tumor budding
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tcr.2019.11.28). The authors have 
      no conflicts of interest to declare.
EDAT- 2020/01/01 00:00
MHDA- 2020/01/01 00:01
PMCR- 2020/01/01
CRDT- 2022/02/04 05:50
PHST- 2019/05/08 00:00 [received]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2022/02/04 05:50 [entrez]
PHST- 2020/01/01 00:00 [pubmed]
PHST- 2020/01/01 00:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - tcr-09-01-119 [pii]
AID - 10.21037/tcr.2019.11.28 [doi]
PST - ppublish
SO  - Transl Cancer Res. 2020 Jan;9(1):119-127. doi: 10.21037/tcr.2019.11.28.