PMID- 35117565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220205
IS  - 2219-6803 (Electronic)
IS  - 2218-676X (Print)
IS  - 2218-676X (Linking)
VI  - 9
IP  - 3
DP  - 2020 Mar
TI  - The role of inflammatory cytokines in the development of idiopathic subglottic 
      stenosis.
PG  - 2102-2107
LID - 10.21037/tcr.2019.12.37 [doi]
AB  - Idiopathic subglottic stenosis (iSGS) is a debilitating extrathoracic obstruction 
      involving the lower laryngeal and upper tracheal airway. It arises without a 
      known antecedent injury or associated disease process. iSGS is a fibrotic disease 
      marked histologically by excessive accumulation of fibrous connective tissue 
      components of the extracellular matrix (ECM, i.e., collagen and fibronectin) in 
      inflamed tissue, which leads to airway obstruction and clinical dyspnea. Diverse 
      diseases in divergent organ systems are associated with fibrosis, suggesting 
      common pathogenic pathways. One of the most common is sustained host 
      inflammation. Recent investigations focusing on the inflammatory response 
      associated with iSGS have sought to characterize the immunophenotype and cytokine 
      profile of the airway scar in iSGS. While the role of the immune response as 
      inciting event in iSGS remains unresolved, the centrality of an active immune 
      response to the observed subglottic tissue remodeling is becoming more defined.
CI  - 2020 Translational Cancer Research. All rights reserved.
FAU - Motz, Kevin M
AU  - Motz KM
AD  - Department of Otolaryngology & Head and Neck Surgery, Johns Hopkins School of 
      Medicine, Baltimore, MD, USA.
FAU - Gelbard, Alexander
AU  - Gelbard A
AD  - Department of Otolaryngology & Head and Neck Surgery, Vanderbilt University 
      Medical Center, Nashville, TN, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Transl Cancer Res
JT  - Translational cancer research
JID - 101585958
PMC - PMC8797976
OTO - NOTNLM
OT  - Idiopathic subglottic stenosis (iSGS)
OT  - immunity
OT  - interleukin-17A (IL-17A)
OT  - transforming growth factor beta (TGF-beta)
COIS- Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tcr.2019.12.37). The series "Recent 
      Developments in Benign Tracheal Stenosis" was commissioned by the editorial 
      office without any funding or sponsorship. The authors have no other conflicts of 
      interest to declare.
EDAT- 2020/03/01 00:00
MHDA- 2020/03/01 00:01
PMCR- 2020/03/01
CRDT- 2022/02/04 05:51
PHST- 2019/07/08 00:00 [received]
PHST- 2019/12/05 00:00 [accepted]
PHST- 2022/02/04 05:51 [entrez]
PHST- 2020/03/01 00:00 [pubmed]
PHST- 2020/03/01 00:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - tcr-09-03-2102 [pii]
AID - 10.21037/tcr.2019.12.37 [doi]
PST - ppublish
SO  - Transl Cancer Res. 2020 Mar;9(3):2102-2107. doi: 10.21037/tcr.2019.12.37.