PMID- 35117591
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2219-6803 (Electronic)
IS  - 2218-676X (Print)
IS  - 2218-676X (Linking)
VI  - 9
IP  - 4
DP  - 2020 Apr
TI  - The prognostic roles of red blood cell-associated indicators in patients with 
      resectable gastric cancers.
PG  - 2300-2311
LID - 10.21037/tcr.2020.03.46 [doi]
AB  - BACKGROUND: Gastric cancer (GC) is one of the leading causes of cancer-related 
      death worldwide. This study was designed to investigate the prognostic values of 
      red blood cell (RBC)-associated indicators, including RBC, hemoglobin (HGB), 
      hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      (MCH), mean corpuscular hemoglobin concentration (MCHC), and RBC distribution 
      width (RDW) in resectable GC patients. METHODS: In this retrospective study, a 
      total of 104 pathologically confirmed GC patients were recruited. These cases 
      were divided into two groups according to the median values of pretreatment RBC, 
      HGB, HCT, MCV, MCH, MCHC, or RDW. To evaluate the changes in RBC-associated 
      indicators values after treatment, we introduced the concept of 
      post-/pre-treatment ratios (</=1 suggested RBC, HGB, HCT, MCV, MCH, MCHC, or RDW 
      values were not increased after therapy, while >1 represented those in increased 
      levels). RESULTS: The lower pretreatment MCHC levels were correlated with worse 
      overall survival (OS), while pretreatment levels of RBC, HGB, HCT, MCV, MCH, or 
      RDW were not. The whole course of treatment (surgery plus adjuvant chemotherapy) 
      significantly decreased the values of MCHC, and increased the values of MCV and 
      RDW, whereas it had no obvious effects on the values of RBC, HGB, HCT, or MCH. 
      Patients with post-/pre-treatment MCV ratio >1 had an increased survival ratio. 
      Meanwhile, post-/pre-treatment RBC, HGB, HCT, MCH, MCHC, or RDW ratios were not 
      correlated with outcomes. Multivariate Cox regression analysis revealed that the 
      American Joint Committee on Cancer (AJCC) stage (III), and lower pretreatment 
      MCHC levels were independent risk factors affecting OS. The receiver operating 
      characteristic (ROC) curve analysis showed that an MCHC value of 341.98 g/L was 
      the optimal cutoff value for prognosis, with a sensitivity of 58.3% and a 
      specificity of 75.0%. CONCLUSIONS: Pretreatment MCHC levels could become a 
      potential prognostic factor for resectable GC.
CI  - 2020 Translational Cancer Research. All rights reserved.
FAU - Cui, Meng-Ting
AU  - Cui MT
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
AD  - Department of Oncology, Zhangjiagang No.1 People's Hospital, Suzhou 215600, 
      China.
FAU - Liang, Zhan-Wen
AU  - Liang ZW
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
FAU - Sun, Yi-Zhang
AU  - Sun YZ
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
AD  - School of Clinical Medicine, Jining Medical University, Jining 272000, China.
FAU - Wu, Jing
AU  - Wu J
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Lu, Hong
AU  - Lu H
AD  - Department of Radiation Oncology, The First Affiliated Hospital of Soochow 
      University, Suzhou 215006, China.
AD  - Department of Oncology, Changshu No.1 People's Hospital, Suzhou 215500, China.
FAU - Wang, Wen-Jie
AU  - Wang WJ
AD  - Department of Radio-Oncology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou 215001, China.
FAU - Xu, Meng-Dan
AU  - Xu MD
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
FAU - Jiang, Min
AU  - Jiang M
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
AD  - Comprehensive Cancer Center, Suzhou Xiangcheng People's Hospital, Suzhou 215000, 
      China.
FAU - Qian, Jun
AU  - Qian J
AD  - Department of Oncology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou 215001, China.
AD  - Suzhou Cancer Medical Center, Suzhou Municipal Hospital, Suzhou 215001, China.
FAU - Duan, Wei-Ming
AU  - Duan WM
AD  - Department of Oncology, The First Affiliated Hospital of Soochow University, 
      Suzhou 215006, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Cancer Res
JT  - Translational cancer research
JID - 101585958
PMC - PMC8797860
OTO - NOTNLM
OT  - Gastric cancer (GC)
OT  - prognosis
OT  - red blood cell-associated indicators (RBC-associated indicators)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tcr.2020.03.46). The authors have 
      no conflicts of interest to declare.
EDAT- 2020/04/01 00:00
MHDA- 2020/04/01 00:01
PMCR- 2020/04/01
CRDT- 2022/02/04 05:51
PHST- 2019/07/04 00:00 [received]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2022/02/04 05:51 [entrez]
PHST- 2020/04/01 00:00 [pubmed]
PHST- 2020/04/01 00:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - tcr-09-04-2300 [pii]
AID - 10.21037/tcr.2020.03.46 [doi]
PST - ppublish
SO  - Transl Cancer Res. 2020 Apr;9(4):2300-2311. doi: 10.21037/tcr.2020.03.46.