PMID- 35118717
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230411
IS  - 1941-2452 (Electronic)
IS  - 0884-5336 (Print)
IS  - 0884-5336 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Feb
TI  - Pilot study on the impact of a carbohydrate loading drink on postprandial 
      glycemic responses and gastric emptying in adults with prediabetes and type 2 
      diabetes mellitus.
PG  - 108-117
LID - 10.1002/ncp.10845 [doi]
AB  - BACKGROUND: Preoperative carbohydrate (CHO) loading improves patient outcomes but 
      is not extensively studied in individuals with diabetes mellitus (DM), resulting 
      in limited professional recommendations. This study examined postprandial 
      glycemic responses and gastric emptying rates following consumption of a CHO 
      drink in adults with and without DM. METHODS: A single-arm, nonrandomized pilot 
      trial was conducted in adults without DM (non-DM) (47.5 +/- 2.5 years), with pre-DM 
      (55.8 +/- 3.0 years), and with type 2 DM (56.2 +/- 2.5 years). Following an overnight 
      fast, participants consumed a 50 g CHO drink followed by 1.5 g liquid 
      paracetamol. Venous blood samples were collected at baseline (ie, t = 0 min) and 
      15, 30, 45, 60, 90, 120, 150, 180, 210, and 240 min for plasma glucose and serum 
      insulin and paracetamol concentrations to assess gastric emptying. RESULTS: 
      Participants with DM were older and had a higher body mass index than non-DM 
      participants (31.2 +/- 0.9 vs 28.2 +/- 0.9). Fasting glucose and hemoglobin A1c 
      levels differed significantly across groups (non-DM: 95.4 +/- 3.6 mg/dl and 
      5.2% +/- 0.1%; pre-DM: 111.6 +/- 3.6 mg/dl and 5.8% +/- 0.1%; DM: 167.4 +/- 3.6 mg/dl and 
      7.2% +/- 0.1%). Compared with the non-DM group, DM had increased glucose responses 
      at 30-180 min. Glucose returned to baseline at 150 min in the non-DM and pre-DM 
      groups compared with 210 min in the DM group. Paracetamol concentrations were not 
      significantly different between the non-DM and DM groups. CONCLUSION: Blood 
      glucose returned to baseline within ~2.5 h in non-DM and pre-DM groups and ~3.5 h 
      in participants with DM following ingestion of a CHO drink. No consistent 
      differences in gastric emptying rates were observed between participants with and 
      without DM.
CI  - (c) 2022 Abbott Nutrition. Nutrition in Clinical Practice published by Wiley 
      Periodicals LLC on behalf of American Society for Parenteral and Enteral 
      Nutrition.
FAU - Cassady, Bridget A
AU  - Cassady BA
AUID- ORCID: 0000-0002-2995-0259
AD  - Scientific and Medical Affairs, Abbott Nutrition, Columbus, OH, USA.
FAU - McDonald, Joshua D
AU  - McDonald JD
AD  - Scientific and Medical Affairs, Abbott Nutrition, Columbus, OH, USA.
FAU - Yalawar, Menaka
AU  - Yalawar M
AD  - Statistical Services, Cognizant Technology Solutions Pvt Ltd, Bangalore, India.
FAU - Baggs, Geraldine E
AU  - Baggs GE
AD  - Scientific and Medical Affairs, Abbott Nutrition, Columbus, OH, USA.
FAU - Maki, Kevin C
AU  - Maki KC
AD  - Midwest Biomedical Research, Chicago, IL, USA.
LA  - eng
GR  - Abbott Laboratories/
PT  - Journal Article
DEP - 20220204
PL  - United States
TA  - Nutr Clin Pract
JT  - Nutrition in clinical practice : official publication of the American Society for 
      Parenteral and Enteral Nutrition
JID - 8606733
RN  - 362O9ITL9D (Acetaminophen)
RN  - 0 (Insulin)
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Diabetes Mellitus, Type 2
MH  - Gastric Emptying/physiology
MH  - *Prediabetic State
MH  - Pilot Projects
MH  - Diet, Carbohydrate Loading
MH  - Acetaminophen
MH  - Insulin
MH  - Blood Glucose
MH  - Glucose
PMC - PMC10078677
OTO - NOTNLM
OT  - carbohydrate loading
OT  - diabetes mellitus
OT  - enhanced recover after surgery
OT  - enhanced recovery pathways
OT  - gastric emptying
OT  - glycemic control
COIS- Bridget A. Cassady and Geraldine E. Baggs are employees and stockholders. Joshua 
      D. McDonald was a contract scientist at Abbott Nutrition during the completion of 
      this study. Menaka Yalawar is a current contract scientist at Abbott Nutrition. 
      Kevin C. Maki is the Chief Scientist of Midwest Biomedical Research, which 
      received a fee for service from Abbott Nutrition for conducting participant 
      visits, and served as a consultant on the study.
EDAT- 2022/02/05 06:00
MHDA- 2023/01/11 06:00
PMCR- 2023/04/06
CRDT- 2022/02/04 05:56
PHST- 2021/11/29 00:00 [revised]
PHST- 2021/07/21 00:00 [received]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/02/05 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/02/04 05:56 [entrez]
PHST- 2023/04/06 00:00 [pmc-release]
AID - NCP10845 [pii]
AID - 10.1002/ncp.10845 [doi]
PST - ppublish
SO  - Nutr Clin Pract. 2023 Feb;38(1):108-117. doi: 10.1002/ncp.10845. Epub 2022 Feb 4.