PMID- 35120597
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 40
IP  - 2
DP  - 2022 Feb 14
TI  - Inflammatory fibroblasts make rectal cancer resistant to radiation therapy.
PG  - 122-124
LID - S1535-6108(22)00007-1 [pii]
LID - 10.1016/j.ccell.2022.01.005 [doi]
AB  - Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Still, 
      the molecular mechanisms that drive CRC therapy resistance are incompletely 
      understood. In this issue of Cancer Cell, Nicolas et al. combine several 
      approaches to unravel a critical role for inflammatory cancer-associated 
      fibroblasts (iCAFs) and interleukin 1alpha (IL1alpha) signaling in radiotherapy 
      resistance.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Mhaidly, Rana
AU  - Mhaidly R
AD  - Institut Curie, Stress and Cancer Laboratory, Equipe labelisee par la Ligue 
      Nationale contre le Cancer, PSL Research University, 26, Rue d'Ulm, 75248 Paris, 
      France; Inserm, U830, 26, Rue d'Ulm, 75005 Paris, France.
FAU - Mechta-Grigoriou, Fatima
AU  - Mechta-Grigoriou F
AD  - Institut Curie, Stress and Cancer Laboratory, Equipe labelisee par la Ligue 
      Nationale contre le Cancer, PSL Research University, 26, Rue d'Ulm, 75248 Paris, 
      France; Inserm, U830, 26, Rue d'Ulm, 75005 Paris, France. Electronic address: 
      fatima.mechta-grigoriou@curie.fr.
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220203
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
SB  - IM
CON - Cancer Cell. 2022 Feb 14;40(2):168-184.e13. PMID: 35120600
MH  - *Cancer-Associated Fibroblasts
MH  - Fibroblasts
MH  - Humans
MH  - *Rectal Neoplasms/radiotherapy
COIS- Declaration of interests F.M-G. received research support from Innate-Pharma, 
      Roche and Bristol-Myers-Squibb (BMS). R.M. declares no potential conflict of 
      interest.
EDAT- 2022/02/06 06:00
MHDA- 2022/03/05 06:00
CRDT- 2022/02/05 05:33
PHST- 2022/02/06 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
PHST- 2022/02/05 05:33 [entrez]
AID - S1535-6108(22)00007-1 [pii]
AID - 10.1016/j.ccell.2022.01.005 [doi]
PST - ppublish
SO  - Cancer Cell. 2022 Feb 14;40(2):122-124. doi: 10.1016/j.ccell.2022.01.005. Epub 
      2022 Feb 3.