PMID- 35120788
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221018
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 51
IP  - 10
DP  - 2022 Oct
TI  - Chondrotoxic effects of intra-articular injection of local anaesthetics in the 
      rabbit temporomandibular joint.
PG  - 1337-1344
LID - S0901-5027(22)00026-1 [pii]
LID - 10.1016/j.ijom.2022.01.011 [doi]
AB  - The aim of this study was to investigate the chondrotoxic effects of a 
      single-dose intra-articular injection of articaine, lidocaine, and bupivacaine on 
      the rabbit temporomandibular joint (TMJ). Twenty-four rabbits were divided into 
      four groups: control (group 1), articaine (group 2), lidocaine (group 3), and 
      bupivacaine (group 4). Synovial fluid samples and venous blood were taken to 
      evaluate matrix metalloproteinase 3 (MMP-3) levels. One millilitre of local 
      anaesthetic solution was injected in the study groups and saline solution in the 
      control group. The rabbits were euthanized after 4 weeks and the mandibular 
      condyles and articular discs were evaluated. On histological examination, the 
      study group samples had irregular joint surfaces, decreased collagen, and a 
      thinner cartilage layer. Apoptotic cells were evaluated with the TUNEL method. 
      TUNEL-positive apoptotic cell counts were higher in all study groups compared to 
      the control group, and the difference was significant (P < 0.001). The mean 
      preoperative serum MMP-3 level for all groups was 5.71 +/- 3.33 ng/mL, while the 
      mean postoperative level was 22.61 +/- 6.36 ng/mL; this difference was significant 
      (P < 0.001). A single-dose intra-articular injection of local anaesthetic had 
      apoptotic effects on chondrocytes, leading to degenerative changes in the TMJ 
      articular structures. Articaine was found to have less harmful effects than 
      lidocaine and bupivacaine. Intra-articular injection of local anaesthetics should 
      be limited in the TMJ because of the potential toxic effects.
CI  - Copyright (c) 2022 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Inc. All rights reserved.
FAU - Asan, C Y
AU  - Asan CY
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes 
      University, Kayseri, Turkey. Electronic address: dtcanayasan@gmail.com.
FAU - Agyuz, G
AU  - Agyuz G
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes 
      University, Kayseri, Turkey.
FAU - Canpolat, D G
AU  - Canpolat DG
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes 
      University, Kayseri, Turkey.
FAU - Demirbas, A E
AU  - Demirbas AE
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes 
      University, Kayseri, Turkey.
FAU - Asan, M
AU  - Asan M
AD  - Department of Anaesthesiology and Reanimation, Kayseri City Hospital, Kayseri, 
      Turkey.
FAU - Yay, A
AU  - Yay A
AD  - Department of Histology and Embryology, Faculty of Medicine, Erciyes University, 
      Kayseri, Turkey.
FAU - Ulger, M
AU  - Ulger M
AD  - Department of Histology and Embryology, Faculty of Medicine, Erciyes University, 
      Kayseri, Turkey.
FAU - Karakukcu, C
AU  - Karakukcu C
AD  - Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220201
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
RN  - 0 (Anesthetics, Local)
RN  - 0 (Saline Solution)
RN  - 98PI200987 (Lidocaine)
RN  - D3SQ406G9X (Carticaine)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - *Anesthetics, Local/toxicity
MH  - Animals
MH  - Bupivacaine/toxicity
MH  - Carticaine/toxicity
MH  - *Cartilage, Articular
MH  - Injections, Intra-Articular
MH  - Lidocaine/toxicity
MH  - Matrix Metalloproteinase 3/pharmacology
MH  - Rabbits
MH  - Saline Solution/pharmacology
MH  - Temporomandibular Joint
OTO - NOTNLM
OT  - TMJ
OT  - articaine
OT  - bupivacaine
OT  - lidocaine
OT  - local anesthetic
OT  - temporomandibular joint
OT  - ultracaine
EDAT- 2022/02/06 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/02/05 05:36
PHST- 2021/04/22 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/06 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/02/05 05:36 [entrez]
AID - S0901-5027(22)00026-1 [pii]
AID - 10.1016/j.ijom.2022.01.011 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2022 Oct;51(10):1337-1344. doi: 
      10.1016/j.ijom.2022.01.011. Epub 2022 Feb 1.