PMID- 35120983
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220714
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 245
DP  - 2022 Jun
TI  - Pediatric Prescriptions of Proton Pump Inhibitors in France (2009-2019): 
      A Time-Series Analysis of Trends and Practice Guidelines Impact.
PG  - 158-164.e4
LID - S0022-3476(22)00072-5 [pii]
LID - 10.1016/j.jpeds.2022.01.041 [doi]
AB  - OBJECTIVE: To describe the ambulatory proton pump inhibitor (PPI) prescription in 
      French children, its trends, and the impact of French (2014) and international 
      (2018) clinical guidelines. STUDY DESIGN: We described PPI prescription rates 
      based on national dispensation data in French children (IQVIA's Xponent database, 
      2009-2019). Using a segmented linear regression, we assessed the impact of 
      clinical guidelines on PPI prescription rates. Analyses were performed for the 
      overall pediatric population and by age subgroups (infants <2 years old, children 
      2-11 years old, adolescents 12-17 years old). RESULTS: During the study period, 8 
      060 288 pediatric PPI prescriptions were filled, with a mean PPI prescription 
      rate of 52.5 per 1000 inhabitants per year. Between 2009 and 2019, the PPI 
      prescription rate increased by 41% in the overall pediatric population (+110% in 
      infants). The PPI prescription rate showed seasonal patterns with peaks in 
      winter. After the release of French guidelines, significant decreases in trends 
      of prescription rates occurred overall (change in trend -0.28, 95% CI 
      -0.34;-0.23) and across all age groups. In infants, this change in trend was not 
      sufficient to reverse the PPI prescription rate that was still increasing over 
      time. In children, the PPI prescription rate slightly decreased and in 
      adolescents, it was stable. After the release of international guidelines, a 
      significant decrease in trend occurred in adolescents only (change in trend 
      -0.26, 95% CI -0.47; -0.04). CONCLUSIONS: The pediatric PPI prescription rate in 
      France was high, displayed a major increase over the last decade, mainly among 
      infants, and was modestly affected by clinical guidelines.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Yang, Shuai
AU  - Yang S
AD  - Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, 
      Research Centre for Epidemiology and Statistics (CRESS), Universite de Paris, 
      Paris, France.
FAU - Trinh, Nhung T H
AU  - Trinh NTH
AD  - Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, 
      Research Centre for Epidemiology and Statistics (CRESS), Universite de Paris, 
      Paris, France; IQVIA, La Defense, France.
FAU - Chalumeau, Martin
AU  - Chalumeau M
AD  - Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, 
      Research Centre for Epidemiology and Statistics (CRESS), Universite de Paris, 
      Paris, France; Department of General Pediatrics and Pediatric Infectious 
      Diseases, Necker-Enfants malades Hospital, Assistance Publique-Hopitaux de Paris, 
      Universite de Paris, Paris, France. Electronic address: 
      martin.chalumeau@inserm.fr.
FAU - Kaguelidou, Florentia
AU  - Kaguelidou F
AD  - Department of Pediatric Pharmacology and Pharmacogenetics, Robert-Debre Hospital, 
      Assistance Publique-Hopitaux de Paris, Universite de Paris, Paris, France; 
      Inserm, Clinical Investigation Center, Paris, France.
FAU - Ruemmele, Frank M
AU  - Ruemmele FM
AD  - Pediatric Gastroenterology Hepatology and Nutrition, Necker-Enfants malades 
      Hospital, Assistance Publique-Hopitaux de Paris, Universite de Paris, Paris, 
      France; Institut Imagine, Inserm U 1163, Paris, France.
FAU - Milic, Dejan
AU  - Milic D
AD  - IQVIA, La Defense, France.
FAU - Lemaitre, Magali
AU  - Lemaitre M
AD  - IQVIA, La Defense, France.
FAU - Cohen, Jeremie F
AU  - Cohen JF
AD  - Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, 
      Research Centre for Epidemiology and Statistics (CRESS), Universite de Paris, 
      Paris, France; Department of General Pediatrics and Pediatric Infectious 
      Diseases, Necker-Enfants malades Hospital, Assistance Publique-Hopitaux de Paris, 
      Universite de Paris, Paris, France.
FAU - Taine, Marion
AU  - Taine M
AD  - Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, 
      Research Centre for Epidemiology and Statistics (CRESS), Universite de Paris, 
      Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20220201
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual
MH  - Drug Prescriptions
MH  - France/epidemiology
MH  - Humans
MH  - Infant
MH  - Practice Patterns, Physicians'
MH  - *Prescriptions
MH  - *Proton Pump Inhibitors/therapeutic use
MH  - Research Design
OTO - NOTNLM
OT  - France
OT  - clinical guideline
OT  - pediatric population
OT  - prescription rate
OT  - proton pump inhibitor
OT  - time-series analysis
EDAT- 2022/02/06 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/02/05 05:37
PHST- 2021/11/01 00:00 [received]
PHST- 2021/12/28 00:00 [revised]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/02/06 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/02/05 05:37 [entrez]
AID - S0022-3476(22)00072-5 [pii]
AID - 10.1016/j.jpeds.2022.01.041 [doi]
PST - ppublish
SO  - J Pediatr. 2022 Jun;245:158-164.e4. doi: 10.1016/j.jpeds.2022.01.041. Epub 2022 
      Feb 1.