PMID- 35121182
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220416
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 250
DP  - 2022 Apr 15
TI  - Gaining insight into the neural basis of resting-state fMRI signal.
PG  - 118960
LID - S1053-8119(22)00089-1 [pii]
LID - 10.1016/j.neuroimage.2022.118960 [doi]
AB  - The blood oxygenation level-dependent (BOLD)-based resting-state functional 
      magnetic resonance imaging (rsfMRI) has been widely used as a non-invasive tool 
      to map brain-wide connectivity architecture. However, the neural basis 
      underpinning the resting-state BOLD signal remains elusive. In this study, we 
      combined simultaneous calcium-based fiber photometry with rsfMRI in awake animals 
      to examine the relationship of the BOLD signal and spiking activity at the 
      resting state. We observed robust couplings between calcium and BOLD signals in 
      the dorsal hippocampus as well as other distributed areas in the default mode 
      network (DMN), suggesting that the calcium measurement can reliably predict the 
      rsfMRI signal. In addition, using the calcium signal recorded as the ground 
      truth, we assessed the impacts of different rsfMRI data preprocessing pipelines 
      on functional connectivity mapping. Overall, our results provide important 
      evidence suggesting that spiking activity measured by the calcium signal plays a 
      key role in the neural mechanism of resting-state BOLD signal.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Ma, Zilu
AU  - Ma Z
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, USA.
FAU - Zhang, Qingqing
AU  - Zhang Q
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, USA.
FAU - Tu, Wenyu
AU  - Tu W
AD  - The Huck Institutes of the Life Sciences, The Pennsylvania State University, 
      University Park, USA.
FAU - Zhang, Nanyin
AU  - Zhang N
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, USA; The Huck Institutes of the Life Sciences, The Pennsylvania 
      State University, University Park, USA. Electronic address: nuz2@psu.edu.
LA  - eng
GR  - R01 GM141792/GM/NIGMS NIH HHS/United States
GR  - R01 NS085200/NS/NINDS NIH HHS/United States
GR  - RF1 MH114224/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220201
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Default Mode Network/*diagnostic imaging/*metabolism
MH  - Hippocampus/diagnostic imaging/metabolism
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Rats
MH  - Rats, Long-Evans
PMC - PMC8935501
MID - NIHMS1785793
OTO - NOTNLM
OT  - Awake
OT  - GCaMP
OT  - Preprocessing
OT  - Rat
OT  - Resting-state fMRI
COIS- Declaration of Competing Interest none.
EDAT- 2022/02/06 06:00
MHDA- 2022/03/18 06:00
PMCR- 2022/04/15
CRDT- 2022/02/05 05:38
PHST- 2021/12/21 00:00 [received]
PHST- 2022/01/30 00:00 [revised]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/06 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2022/02/05 05:38 [entrez]
PHST- 2022/04/15 00:00 [pmc-release]
AID - S1053-8119(22)00089-1 [pii]
AID - 10.1016/j.neuroimage.2022.118960 [doi]
PST - ppublish
SO  - Neuroimage. 2022 Apr 15;250:118960. doi: 10.1016/j.neuroimage.2022.118960. Epub 
      2022 Feb 1.