PMID- 35122432
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 62
IP  - 2
DP  - 2022 Feb
TI  - Migraine and large artery atherosclerosis in young adults with ischemic stroke.
PG  - 191-197
LID - 10.1111/head.14265 [doi]
AB  - INTRODUCTION: Migraine is a risk factor for ischemic stroke, but the mechanisms 
      of stroke associated with migraine are debated. The aim of this study was to 
      investigate the association between migraine and large artery atherosclerosis 
      (LAA) in young adults with ischemic stroke. METHODS: Patients aged between 18 and 
      54 years consecutively treated for first acute ischemic stroke in a university 
      hospital stroke unit between January 2017 and December 2019 were included in this 
      cross-sectional study. Migraine status was systematically assessed by the same 
      headache specialist. Stenotic and nonstenotic LAA of extracranial and 
      intracranial cerebral arteries were evaluated and graded using the ASCOD 
      (atherosclerosis, small-vessel disease, cardiac pathology, other causes, 
      dissection) criteria. We adjusted the association between migraine and LAA for 
      traditional risk factors. RESULTS: A total of 415 patients were included (mean 
      age [standard deviation], 43.9 [8.7] years; 258/415 [62.2%] men). Migraine with 
      aura (MWA) was diagnosed in 76 patients, and migraine without aura (MWoA) in 68 
      patients. Patients with migraine had fewer traditional cardiovascular risk 
      factors. Stenotic LAA (10/144 [6.9%] vs. 42/271 [15.5%]; p < 0.001) and LAA of 
      any grade (35/144 [24.3%] vs. 138/271 [50.9%]; p < 0.001) were significantly less 
      frequent in patients with migraine than in patients without migraine, 
      respectively. Multivariable analysis adjusting for age, sex, overweight, tobacco 
      use, hypertension, diabetes, and hyperlipidemia showed a negative association 
      between migraine and LAA of any grade (odds ratio [OR] = 0.44, 95% confidence 
      interval [CI: 0.254-0.78], p = 0.005). This negative association was found for 
      both MWoA (OR = 0.42, 95% CI [0.204-0.88], p = 0.020) and MWA (OR = 0.47, 95% CI 
      [0.228-0.96], p = 0.037) compared to no migraine. CONCLUSION: In this study of 
      young adults with ischemic stroke, migraine had a negative association with LAA. 
      This negative association was independent of traditional vascular risk factors 
      and was found for both MWA and MWoA.
CI  - (c) 2022 American Headache Society.
FAU - Gollion, Cedric
AU  - Gollion C
AD  - Department of Neurology, University Hospital of Toulouse, Toulouse, France.
AD  - ToNIC, Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, 
      Toulouse, France.
FAU - Guidolin, Brigitte
AU  - Guidolin B
AD  - Department of Neurology, University Hospital of Toulouse, Toulouse, France.
FAU - Lerebours, Fleur
AU  - Lerebours F
AD  - Department of Neurology, University Hospital of Toulouse, Toulouse, France.
FAU - Rousseau, Vanessa
AU  - Rousseau V
AD  - Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and 
      Pharmacoepidemiology, INSERM UMR 1027, CIC 1426, Toulouse University Hospital, 
      Faculty of Medicine, University of Toulouse, Toulouse, France.
FAU - Barbieux-Guillot, Marianne
AU  - Barbieux-Guillot M
AD  - Department of Neurology, University Hospital of Toulouse, Toulouse, France.
FAU - Larrue, Vincent
AU  - Larrue V
AD  - Department of Neurology, University Hospital of Toulouse, Toulouse, France.
LA  - eng
PT  - Journal Article
DEP - 20220205
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Intracranial Arteriosclerosis/epidemiology
MH  - Ischemic Stroke/*epidemiology
MH  - Male
MH  - Migraine with Aura/*physiopathology
MH  - Migraine without Aura/*physiopathology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - large artery atherosclerosis
OT  - migraine
OT  - migraine with aura
OT  - stroke
OT  - stroke in young adults
EDAT- 2022/02/06 06:00
MHDA- 2022/03/11 06:00
CRDT- 2022/02/05 08:33
PHST- 2021/11/12 00:00 [revised]
PHST- 2021/07/14 00:00 [received]
PHST- 2021/12/01 00:00 [accepted]
PHST- 2022/02/06 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/02/05 08:33 [entrez]
AID - 10.1111/head.14265 [doi]
PST - ppublish
SO  - Headache. 2022 Feb;62(2):191-197. doi: 10.1111/head.14265. Epub 2022 Feb 5.