PMID- 35123423
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220216
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Feb 5
TI  - Do biometric parameters improve the quality of optic nerve head measurements with 
      spectral domain optical coherence tomography?
PG  - 56
LID - 10.1186/s12886-022-02281-6 [doi]
LID - 56
AB  - BACKGROUND: Spectral domain optical coherence tomography (SD-OCT) is a widely 
      applied non-invasive technique for evaluating optic nerve head parameters. The 
      aim of this study was to evaluate the impact of biometric parameters such as the 
      spherical equivalent (SE) and the anterior corneal curvature (ACC) on the 
      peripapillary retinal nerve fiber layer (pRNFL), Bruch's membrane opening (BMO), 
      and the minimum rim width (MRW) measurements performed by spectral domain optical 
      coherence tomography (SD-OCT) in glaucomatous and healthy eyes. METHODS: In this 
      cross-sectional, case-control prospective pilot study, the glaucoma group 
      consisted of 50 patients with previously diagnosed and treated glaucoma and one 
      healthy group of 50 subjects. Two consecutive examinations of pRNFL, BMO, and MRW 
      with SD-OCT for every patient were performed without ACC and objective refraction 
      (imaging 1) and with them (imaging 2). RESULTS: The interclass correlation 
      coefficient (ICC) reflected high agreement between imaging 1 and imaging 2 in 
      both groups. The ICC in the glaucoma and healthy groups for pRNFL (0.99 vs. 
      0.98), BMO (0.95 vs. 0.97), and MRW (1.0 vs. 1.0) was comparable. CONCLUSIONS: 
      Our preliminary data from a small number of eyes showed that the measurements of 
      pRNFL, MRW, and BMO reflected high agreement between both imaging techniques with 
      ACC and objective refraction and without these parameters in subjects with a 
      refractive error up to +/- 6.0 diopters. Further studies with participants with 
      higher refractive error are necessary to evaluate the impact of biometric 
      parameters such as SE and ACC on measurements with SD-OCT.
CI  - (c) 2022. The Author(s).
FAU - Elksne, E
AU  - Elksne E
AD  - Department of Ophthalmology, Riga Stradins University, Dzirciema iela 16, Riga, 
      1007, Latvia.
FAU - Stingl, J V
AU  - Stingl JV
AD  - Department of Ophthalmology, University Medical Center, Johannes Gutenberg 
      University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Schuster, A K
AU  - Schuster AK
AD  - Department of Ophthalmology, University Medical Center, Johannes Gutenberg 
      University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Wagner, F M
AU  - Wagner FM
AD  - Department of Ophthalmology, University Medical Center, Johannes Gutenberg 
      University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Hoffmann, E M
AU  - Hoffmann EM
AD  - Department of Ophthalmology, University Medical Center, Johannes Gutenberg 
      University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. ehoffman@uni-mainz.de.
LA  - eng
PT  - Journal Article
DEP - 20220205
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Biometry
MH  - Bruch Membrane
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Intraocular Pressure
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
PMC - PMC8818137
OTO - NOTNLM
OT  - BMO
OT  - MRW
OT  - Optic nerve head
OT  - RNFL
OT  - SD-OCT
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/07 06:00
MHDA- 2022/02/09 06:00
PMCR- 2022/02/05
CRDT- 2022/02/06 20:25
PHST- 2021/07/15 00:00 [received]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/02/06 20:25 [entrez]
PHST- 2022/02/07 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2022/02/05 00:00 [pmc-release]
AID - 10.1186/s12886-022-02281-6 [pii]
AID - 2281 [pii]
AID - 10.1186/s12886-022-02281-6 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2022 Feb 5;22(1):56. doi: 10.1186/s12886-022-02281-6.