PMID- 35123507
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1477-3155 (Electronic)
IS  - 1477-3155 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Feb 5
TI  - Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide 
      nanoparticles on porcine reproductive and respiratory syndrome virus.
PG  - 70
LID - 10.1186/s12951-022-01281-4 [doi]
LID - 70
AB  - BACKGROUND: The infection and spread of porcine reproductive and respiratory 
      syndrome virus (PRRSV) pose a serious threat to the global pig industry, and 
      inhibiting the viral infection process is a promising treatment strategy. 
      Nanomaterials can interact with viruses and have attracted much attention due to 
      their large specific surface area and unique physicochemical properties. Ferrous 
      sulfide nanoparticles (FeS NPs) with the characteristics of high reactivity, 
      large specific surface area, and low cost are widely applied to environmental 
      remediation, catalysis, energy storage and medicine. However, there is no report 
      on the application of FeS NPs in the antiviral field. In this study, gelatin 
      stabilized FeS nanoparticles (Gel-FeS NPs) were large-scale synthesized rapidly 
      by the one-pot method of co-precipitation of Fe(2+) and S(2‒). RESULTS: The 
      prepared Gel-FeS NPs exhibited good stability and dispersibility with an average 
      diameter of 47.3 nm. Additionally, they were characterized with good 
      biocompatibility and high antiviral activity against PRRSV proliferation in the 
      stages of adsorption, invasion, and replication. CONCLUSIONS: We reported for the 
      first time the virucidal and antiviral activity of Gel-FeS NPs. The synthesized 
      Gel-FeS NPs exhibited good dispersibility and biocompatibility as well as 
      effective inhibition on PRRSV proliferation. Moreover, the Fe(2+) released from 
      degraded Gel-FeS NPs still displayed an antiviral effect, demonstrating the 
      advantage of Gel-FeS NPs as an antiviral nanomaterial compared to other 
      nanomaterials. This work highlighted the antiviral effect of Gel-FeS NPs and 
      provided a new strategy for ferrous-based nanoparticles against PRRSV.
CI  - (c) 2022. The Author(s).
FAU - Tong, Ting
AU  - Tong T
AD  - College of Resource and Environment, College of Science, State Key Laboratory of 
      Agricultural Microbiology, Huazhong Agricultural University, No.1 Shizishan 
      Street, Hongshan District, Wuhan, 430070, Hubei, People's Republic of China.
FAU - Deng, Shuangfei
AU  - Deng S
AD  - College of Resource and Environment, College of Science, State Key Laboratory of 
      Agricultural Microbiology, Huazhong Agricultural University, No.1 Shizishan 
      Street, Hongshan District, Wuhan, 430070, Hubei, People's Republic of China.
FAU - Zhang, Xiaotong
AU  - Zhang X
AD  - College of Resource and Environment, College of Science, State Key Laboratory of 
      Agricultural Microbiology, Huazhong Agricultural University, No.1 Shizishan 
      Street, Hongshan District, Wuhan, 430070, Hubei, People's Republic of China.
FAU - Fang, Liurong
AU  - Fang L
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The 
      Cooperative Innovation Center for Sustainable Pig Production, Huazhong 
      Agricultural University, No.1 Shizishan Street, Hongshan District, Wuhan, 430070, 
      Hubei, People's Republic of China.
FAU - Liang, Jiangong
AU  - Liang J
AUID- ORCID: 0000-0002-8210-0210
AD  - College of Resource and Environment, College of Science, State Key Laboratory of 
      Agricultural Microbiology, Huazhong Agricultural University, No.1 Shizishan 
      Street, Hongshan District, Wuhan, 430070, Hubei, People's Republic of China. 
      liangjg@mail.hzau.edu.cn.
FAU - Xiao, Shaobo
AU  - Xiao S
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The 
      Cooperative Innovation Center for Sustainable Pig Production, Huazhong 
      Agricultural University, No.1 Shizishan Street, Hongshan District, Wuhan, 430070, 
      Hubei, People's Republic of China. vet@mail.hzau.edu.cn.
LA  - eng
GR  - 32130103/National Natural Science Foundation of China/
GR  - 31772785/National Natural Science Foundation of China/
GR  - 22074048/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220205
PL  - England
TA  - J Nanobiotechnology
JT  - Journal of nanobiotechnology
JID - 101152208
RN  - 0 (Antiviral Agents)
RN  - 0 (Ferrous Compounds)
RN  - 9000-70-8 (Gelatin)
RN  - TH5J4TUX6S (ferrous sulfide)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/pharmacology
MH  - Ferrous Compounds/pharmacology
MH  - Gelatin
MH  - *Nanoparticles/chemistry
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Swine
PMC - PMC8817501
OTO - NOTNLM
OT  - Adsorption
OT  - Antiviral mechanism
OT  - Ferrous sulfide nanoparticles
OT  - Inactivation
OT  - Invasion
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Release
OT  - Replication
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/07 06:00
MHDA- 2022/04/01 06:00
PMCR- 2022/02/05
CRDT- 2022/02/06 20:25
PHST- 2021/10/21 00:00 [received]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/02/06 20:25 [entrez]
PHST- 2022/02/07 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/02/05 00:00 [pmc-release]
AID - 10.1186/s12951-022-01281-4 [pii]
AID - 1281 [pii]
AID - 10.1186/s12951-022-01281-4 [doi]
PST - epublish
SO  - J Nanobiotechnology. 2022 Feb 5;20(1):70. doi: 10.1186/s12951-022-01281-4.