PMID- 35125882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1178-7066 (Print)
IS  - 1178-7066 (Electronic)
IS  - 1178-7066 (Linking)
VI  - 15
DP  - 2022
TI  - The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and 
      Diabetic Complications in the Chinese Han Population.
PG  - 65-79
LID - 10.2147/PGPM.S347018 [doi]
AB  - BACKGROUND: SOCS2 is downregulated in diabetes, which might be related to 
      diabetes. We explored the effect of SOCS2 polymorphisms on the development of 
      type 2 diabetes mellitus (T2DM) and diabetic complications. METHODS: The subjects 
      consisted of 500 patients with T2DM and 501 healthy controls. Five variants in 
      SOCS2 were genotyped by Agena MassARRAY system. RT-qPCR profiling was performed 
      to detect the expression of SOCS2 mRNA. Logistic regression analysis was utilized 
      to calculate odds ratio (OR) and 95% confidence intervals (95% CIs). RESULTS: 
      Rs3825199 (OR = 1.44, p = 0.007), rs11107116 (OR = 1.39, p = 0.014) and 
      rs10492321 (OR = 1.48, p = 0.004) had an increased T2DM risk of T2DM. Moreover, 
      the contribution of SOCS2 polymorphisms to T2DM risk was associated with age, 
      gender, smoking, drinking, and BMI. SOCS2 variants also had a reduced risk for 
      T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart 
      disease. SOCS2 rs10492321 was the best single locus model. SOCS2 mRNA was 
      downregulated in patients with T2DM compared to healthy controls (p = 0.029). 
      CONCLUSION: This study firstly reported that rs3825199, rs11107116 and rs10492321 
      in SOCS2 conferred to an increased risk for the occurrence of T2DM in the Chinese 
      Han population. Moreover, SOCS2 mRNA was downregulated in patients with T2DM, 
      suggesting that SOCS2 might have an important role in the occurrence of T2DM.
CI  - (c) 2022 Pan et al.
FAU - Pan, Juan
AU  - Pan J
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
AD  - Department of Endocrinology, Xianyang Central Hospital, Xianyang, 712000, 
      Shaanxi, People's Republic of China.
FAU - Tong, Rui
AU  - Tong R
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Deng, Qing
AU  - Deng Q
AD  - Department of Endocrinology, No. 215 Hospital of Shaanxi Nuclear Industry, 
      Xianyang, 712000, Shaanxi, People's Republic of China.
FAU - Tian, Yanni
AU  - Tian Y
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Wang, Ning
AU  - Wang N
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Peng, Yanqi
AU  - Peng Y
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Fei, Sijia
AU  - Fei S
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Cui, Jiaqi
AU  - Cui J
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Guo, Chaoying
AU  - Guo C
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Yao, Juanchuan
AU  - Yao J
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Wei, Cui
AU  - Wei C
AUID- ORCID: 0000-0002-4538-0129
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220129
PL  - New Zealand
TA  - Pharmgenomics Pers Med
JT  - Pharmacogenomics and personalized medicine
JID - 101514107
PMC - PMC8809519
OTO - NOTNLM
OT  - SOCS2 variants
OT  - diabetic complications
OT  - life style
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no conflicts of interest for this work.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2022/01/29
CRDT- 2022/02/07 05:28
PHST- 2021/10/30 00:00 [received]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/02/07 05:28 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2022/01/29 00:00 [pmc-release]
AID - 347018 [pii]
AID - 10.2147/PGPM.S347018 [doi]
PST - epublish
SO  - Pharmgenomics Pers Med. 2022 Jan 29;15:65-79. doi: 10.2147/PGPM.S347018. 
      eCollection 2022.