PMID- 35125946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 46
IP  - 4
DP  - 2021
TI  - Gingival crevicular fluid levels of cytokine, chemokine, and growth factors in 
      patients with periodontitis or gingivitis and periodontally healthy subjects: a 
      cross-sectional multiplex study.
PG  - 474-480
LID - 10.5114/ceji.2021.110289 [doi]
AB  - INTRODUCTION: Gingival crevicular fluid (GCF) is an important resource for 
      detecting inflammatory biomarkers related to periodontal disease. The purpose of 
      this research was to identify the possible relation between cytokine levels and 
      periodontal status. MATERIAL AND METHODS: GCF samples collected from 25 
      periodontally healthy individuals, 24 with gingivitis, and 24 with periodontitis 
      were analyzed using the MAGPIX system with a Bio-Plex Pro Human Cytokine 27-plex 
      kit. Gingival index (GI), periodontal pocket depth (PPD), plaque index (PI), and 
      clinical attachment level (CAL) were measured from each tooth to determine each 
      patient's periodontal status. RESULTS: All clinical parameters showed 
      statistically significant differences between groups. While interleukin (IL)-1beta, 
      IL-6, macrophage chemotactic protein 1 (MCP-1), interferon gamma-induced protein 10 
      (IP-10) and vascular endothelial growth factor (VEGF) levels were statistically 
      significantly higher in patients with periodontitis compared to periodontally 
      healthy subjects, IL-15 levels were found to be statistically significantly 
      higher in periodontally healthy individuals compared to periodontitis (p < 0.05). 
      Also, IL-1beta and IP-10 showed positive correlations with PPD, CAL, GI and bleeding 
      on probing (BOP). CONCLUSIONS: It is considered that IL-1beta, IL-6, IL-15, MCP-1, 
      VEGF and IP-10 could be related to periodontal disease and health and can be used 
      as an adjunct to clinical examination in future research design. Scanning 
      cytokines in GCF with a multiplex immunoassay technique is consequential, 
      especially because many cytokine types are found in one sample.
CI  - Copyright (c) 2021 Termedia.
FAU - Gundogar, Hasan
AU  - Gundogar H
AD  - Department of Surgery and Pediatric Dentistry, Khoja Akhmet Yassawi International 
      Kazakh-Turkish University, Turkestan, Kazakhstan.
AD  - Department of Medical Biochemistry, Faculty of Medicine, University of Gaziantep, 
      Gaziantep, Turkey.
AD  - Department of Periodontology, Faculty of Dentistry, Gaziantep University, Turkey.
FAU - Ustun, Kemal
AU  - Ustun K
AD  - Department of Periodontology, Faculty of Dentistry, Akdeniz University, Turkey.
FAU - Senyurt, Suleyman Ziya
AU  - Senyurt SZ
AD  - Department of Periodontology, Faculty of Dentistry, Gaziantep University, Turkey.
FAU - Ozdemir, Eda Cetin
AU  - Ozdemir EC
AD  - Department of Periodontology, Faculty of Dentistry, Kahramanmaras Sutcu Ifimam 
      University, Turkey.
FAU - Sezer, Ufuk
AU  - Sezer U
AD  - Department of Periodontology, Faculty of Dentistry, Ifistanbul Gelisim 
      University, Turkey.
FAU - Erciyas, Kamile
AU  - Erciyas K
AD  - Department of Periodontology, Faculty of Dentistry, Gaziantep University, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20211225
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC8808303
OTO - NOTNLM
OT  - gingivitis
OT  - laser doppler flow cytometry
OT  - periodontal health
OT  - periodontitis
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2021/01/01
CRDT- 2022/02/07 05:28
PHST- 2021/07/26 00:00 [received]
PHST- 2021/09/28 00:00 [accepted]
PHST- 2022/02/07 05:28 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 45500 [pii]
AID - 10.5114/ceji.2021.110289 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2021;46(4):474-480. doi: 10.5114/ceji.2021.110289. Epub 2021 
      Dec 25.