PMID- 35126088
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Macular Microvasculature Is Associated With Total Cerebral Small Vessel Disease 
      Burden in Recent Single Subcortical Infarction.
PG  - 787775
LID - 10.3389/fnagi.2021.787775 [doi]
LID - 787775
AB  - PURPOSE: To assess the retinal microvasculature, choriocapillaris, and choroidal 
      thickness in recent single subcortical infarction (RSSI) patients compared with 
      healthy controls. We also assessed the correlation between the macular 
      microvascular changes and choroidal changes with their clinical implications in 
      RSSI patients. METHODS: Forty-six RSSI patients and 39 healthy controls (HC) were 
      enrolled in our study. Magnetic resonance imaging (MRI) was done for all RSSI 
      patients, and a total cerebral small vessel disease (CSVD) score was assessed for 
      all patients. Swept-source optical coherence tomography (SS-OCT) was used to 
      image and assess the choroidal thickness and SS-OCT angiography (SS-OCTA) was 
      used to image and assess the macular microvasculature and choriocapillaris in all 
      participants. Clinical information was collected for all participants. RESULTS: 
      RSSI patients showed significantly sparser inner retinal microvasculature (P = 
      0.003) when compared with healthy controls. RSSI patients showed significantly 
      thinner choroidal thickness (P < 0.001) when compared with HC. No significant 
      difference (P = 0.247) was seen when the choriocapillaris was compared between 
      the two groups. CSVD burden (P = 0.014) and NIHSS score (P = 0.010) showed 
      significant correlation with the inner retinal microvasculature of RSSI patients. 
      The inner retinal microvasculature (P = 0.016) and choroidal thickness (P = 
      0.018) showed a significant correlation with the MoCA scores in RSSI patients. 
      CONCLUSIONS: Our report suggests that retinal and choroidal imaging may serve as 
      useful indicators to expand our understanding of RSSI and its clinical validity.
CI  - Copyright (c) 2022 Kwapong, Jiang, Yan, Wan and Wu.
FAU - Kwapong, William Robert
AU  - Kwapong WR
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Jiang, Shuai
AU  - Jiang S
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Yan, Yuying
AU  - Yan Y
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Wan, Jincheng
AU  - Wan J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Wu, Bo
AU  - Wu B
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
LA  - eng
PT  - Journal Article
DEP - 20220120
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8811295
OTO - NOTNLM
OT  - cerebral small vessel disease burden
OT  - macular microvasculature
OT  - magnetic resonance imaging
OT  - recent single subcortical infarction
OT  - swept-source optical coherence tomography angiography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2021/01/01
CRDT- 2022/02/07 05:29
PHST- 2021/10/01 00:00 [received]
PHST- 2021/12/27 00:00 [accepted]
PHST- 2022/02/07 05:29 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.787775 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Jan 20;13:787775. doi: 10.3389/fnagi.2021.787775. 
      eCollection 2021.