PMID- 35127148
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 2075-8251 (Print)
IS  - 2075-8251 (Linking)
VI  - 13
IP  - 4
DP  - 2021 Oct-Dec
TI  - Circulating Actin-Binding Proteins in Laryngeal Cancer: Its Relationship with 
      Circulating Tumor Cells and Cells of the Immune System.
PG  - 64-68
LID - 10.32607/actanaturae.11413 [doi]
AB  - We previously exposed the role of actin-binding proteins (ABPs) in cancer 
      development and progression. In this paper, we studied the relationship between 
      circulating ABPs and the number of ABP-expressing leukocytes and circulating 
      tumor cells (CTCs) in patients with highly aggressive laryngeal squamous cell 
      carcinoma (LSCC). The levels of cofilin (CFL1), profilin (PFN1), ezrin (EZR), 
      fascin (FSCN1), and adenylate cyclase-associated protein 1 (CAP1) were determined 
      using enzyme immunoassay. The ABP expression by the cellular pools was analyzed 
      by flow cytometry. The highest levels of FSCN1 and EZR were found in the blood 
      serum of LSCC patients. There was a difference in ABP expression between the 
      pools of leukocytes and CTCs. Leukocytes were mainly represented by CAP1+ and 
      FSCN1+ pools, and CTCs contained CAP1+, FSCN1+, and EZR+ cells. The serum FSCN1 
      level correlated with the number of FSCN1-containing and CFL1-containing 
      leukocytes. Thus, the level of circulating EZR is likely related to its 
      expression in CTCs. The levels of CFL1 and PFN1 are likely to be supported by the 
      expression of these proteins by leukocytes. Both CTCs and leukocytes can be a 
      source of FSCN1 and CAP1 in blood serum. The results suggest that serum proteins 
      can be produced by various cells, thus indicating both cancer development and the 
      response of the immune system to this process.
CI  - Copyright (R) 2021 National Research University Higher School of Economics.
FAU - Kakurina, G V
AU  - Kakurina GV
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Stakheeva, M N
AU  - Stakheeva MN
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Bakhronov, I A
AU  - Bakhronov IA
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Sereda, E E
AU  - Sereda EE
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Cheremisina, O V
AU  - Cheremisina OV
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Choynzonov, E L
AU  - Choynzonov EL
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
FAU - Kondakova, I V
AU  - Kondakova IV
AD  - Cancer Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, Tomsk, 634050 Russia.
LA  - eng
PT  - Journal Article
PL  - Russia (Federation)
TA  - Acta Naturae
JT  - Acta naturae
JID - 101525823
PMC - PMC8807535
OTO - NOTNLM
OT  - actin-binding proteins
OT  - circulating tumor cells
OT  - laryngeal squamous cell carcinoma
OT  - leukocytes
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2021/10/01
CRDT- 2022/02/07 05:32
PHST- 2021/04/13 00:00 [received]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2022/02/07 05:32 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - 10.32607/actanaturae.11413 [doi]
PST - ppublish
SO  - Acta Naturae. 2021 Oct-Dec;13(4):64-68. doi: 10.32607/actanaturae.11413.