PMID- 35127765
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - ANCA-Associated Vasculitis With Anti-GBM Disease and Two Types of Tumors: A Case 
      Report.
PG  - 810680
LID - 10.3389/fmed.2021.810680 [doi]
LID - 810680
AB  - INTRODUCTION: Anti-neutrophil cytoplasm antibody (ANCA)-associated-vasculitis and 
      anti-glomerular basement membrane (GBM) disease are types of autoimmune diseases 
      that are characterized by the presence of circulating autoantibodies. Most 
      patients with these diseases experience sudden onset, rapid progress, and poor 
      prognosis. The purpose of the present article is to report a case of 
      ANCA-associated vasculitis with anti-GBM disease and two types of tumors. CASE 
      REPORT: A 63-year-old Chinese woman who underwent resection for rectal cancer 6 
      years before and for lung adenocarcinoma 4 years before, presented with fever and 
      nasal obstruction, for the past 2 months and chondritis of an ear for the past 1 
      month. The patient failed to respond to an anti-infection treatment at local and 
      higher-level hospitals with the first episode of "recurrent sinusitis and fever." 
      Later, systemic symptoms such as fatigue, numbness of the limbs, and auricular 
      chondritis gradually aggravated, followed by an increase in inconspicuous 
      hematuria, proteinuria, and serum creatinine level. After admission, the GBM 
      antibody, C-ANCA, and PR3 were positive. The renal puncture was diagnosed as 
      anti-glomerular basement membrane antibody disease. After treatment, her serum 
      creatinine decreased to 104 umol/l. DISCUSSION: In the present report, we 
      introduced the case of a rare double-positive disease in a patient with two types 
      of tumors. Importantly, we noted that colon cancer and lung cancer, PR3, and 
      anti-GBM disease may be related to their pathogenesis and manifestations. Further 
      research is warranted to confirm these hypotheses.
CI  - Copyright (c) 2022 Li, Huang and Liu.
FAU - Li, Xiuxiu
AU  - Li X
AD  - Tongde Hospital of Zhejiang Province, Hangzhou, China.
FAU - Huang, Meichun
AU  - Huang M
AD  - Tongde Hospital of Zhejiang Province, Hangzhou, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Tongde Hospital of Zhejiang Province, Hangzhou, China.
LA  - eng
PT  - Case Reports
DEP - 20220121
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8814105
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody (ANCA)
OT  - colon cancer
OT  - dual antibodies
OT  - glomerular basement membrane (GBM)
OT  - lung cancer
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2022/01/21
CRDT- 2022/02/07 05:35
PHST- 2021/11/07 00:00 [received]
PHST- 2021/12/20 00:00 [accepted]
PHST- 2022/02/07 05:35 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - 10.3389/fmed.2021.810680 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Jan 21;8:810680. doi: 10.3389/fmed.2021.810680. 
      eCollection 2021.