PMID- 35127912
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220208
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 3
DP  - 2022 Jan 21
TI  - Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a 
      family: Two case reports.
PG  - 992-999
LID - 10.12998/wjcc.v10.i3.992 [doi]
AB  - BACKGROUND: Ankylosing spondylitis (AS) is strongly associated with the human 
      leukocyte antigen (HLA) B27 haplotype. In regions where conventional polymerase 
      chain reaction for HLA typing is available for antigens such as HLA B27 or HLA 
      B51, it is common to perform the HLA B27 test for evaluation of AS. While HLA 
      B27-associated clustered occurrences of AS have been reported in families, we 
      report the first case series of HLA B51-related occurrences of AS in a family. 
      CASE SUMMARY: A father and his daughters were diagnosed with AS and did not have 
      the HLA B27 haplotype. Although they were positive for HLA B51, they exhibited no 
      signs of Behcet's disease (BD). Of the five daughters, one had AS, and three, 
      including the daughter with AS, were positive for HLA B51. The two daughters with 
      the HLA B51 haplotype (excluding the daughter with AS) exhibited bilateral grade 
      1 sacroiliitis, whereas the daughters without the HLA B51 haplotype did not have 
      sacroiliitis. Thus, this Korean family exhibited a strong association with the 
      HLA B51 haplotype and clinical sacroiliitis, irrespective of the symptoms of BD. 
      CONCLUSION: It is advisable to check for HLA B51 positivity in patients with 
      AS/spondyloarthropathy who test negative for HLA B27.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Lim, Mie Jin
AU  - Lim MJ
AD  - Rheumatology/Internal Medicine, Inha University, Incheon 22332, South Korea.
FAU - Noh, Eul
AU  - Noh E
AD  - Rheumatology/Internal Medicine, Inha University, Incheon 22332, South Korea.
FAU - Lee, Ro-Woon
AU  - Lee RW
AD  - Radiology, Inha University, Incheon 22332, South Korea.
FAU - Jung, Kyong-Hee
AU  - Jung KH
AD  - Rheumatology/Internal Medicine, Inha University, Incheon 22332, South Korea.
FAU - Park, Won
AU  - Park W
AD  - Rheumatology/Internal Medicine, Inha University, Incheon 22332, South Korea. 
      parkwon@inha.ac.kr.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8790467
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - Case report
OT  - Human leukocyte antigen B27
OT  - Human leukocyte antigen B51
OT  - Sacroiliitis
OT  - Spondyloarthropathy
COIS- Conflict-of-interest statement: The authors have no potential conflicts of 
      interest to disclose.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2022/01/21
CRDT- 2022/02/07 05:35
PHST- 2021/02/26 00:00 [received]
PHST- 2021/10/27 00:00 [revised]
PHST- 2021/12/25 00:00 [accepted]
PHST- 2022/02/07 05:35 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i3.992 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Jan 21;10(3):992-999. doi: 10.12998/wjcc.v10.i3.992.