PMID- 35127917
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220208
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 3
DP  - 2022 Jan 21
TI  - Multiple endocrine neoplasia type 1 combined with thyroid neoplasm: A case report 
      and review of literatures.
PG  - 1032-1040
LID - 10.12998/wjcc.v10.i3.1032 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor 
      syndrome inherited in an autosomal dominant manner and presents mostly as 
      parathyroid, endocrine pancreas (such as gastrinoma) and anterior pituitary 
      tumors. At present, papillary thyroid carcinoma (PTC) and nodular goiter are not 
      regarded as components of MEN1. CASE SUMMARY: A 35-year-old woman presented with 
      MEN1 accompanied by coinstantaneous PTC and nodular goiter. The pathological 
      diagnosis was PTC with cervical lymph node metastasis, nodular goiter, 
      parathyroid cyst and adenomatoid hyperplasia. Genetic testing was performed and a 
      MEN1 gene mutation was detected. The patient underwent unilateral lobectomy of 
      the thyroid gland and surgical removal of the parathyroid tumors. At 18 mo of 
      follow-up, ultrasonic examination of the neck showed no abnormality. Serum 
      calcium and parathyroid hormone levels were normal. No new MEN1-associated tumors 
      were detected. CONCLUSION: The role of inactivating mutations of MEN1 gene in 
      tumorigenesis of PTC and/or nodular goiter remains to be determined by more case 
      reports and further research.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xu, Jia-Lu
AU  - Xu JL
AD  - Department ofThyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, Jilin Province, China.
FAU - Dong, Su
AU  - Dong S
AD  - Department of Anesthesia, The First Hospital of Jilin University, Changchun 
      130021, Jilin Province, China.
FAU - Sun, Le-Le
AU  - Sun LL
AD  - Department ofThyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, Jilin Province, China.
FAU - Zhu, Jin-Xin
AU  - Zhu JX
AD  - Department ofThyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, Jilin Province, China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 
      130012, Jilin Province, China. liu_jia@jlu.edu.cn.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8790451
OTO - NOTNLM
OT  - Case report
OT  - Multiple endocrine neoplasia type 1
OT  - Nodular goiter
OT  - Papillary thyroid carcinoma
OT  - Thyroid cancer
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest.
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2022/01/21
CRDT- 2022/02/07 05:35
PHST- 2021/06/03 00:00 [received]
PHST- 2021/07/07 00:00 [revised]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2022/02/07 05:35 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i3.1032 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Jan 21;10(3):1032-1040. doi: 10.12998/wjcc.v10.i3.1032.