PMID- 35128488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2666-3503 (Electronic)
IS  - 2666-3503 (Linking)
VI  - 3
DP  - 2022
TI  - Zinc deficiency impairs ischemia-induced angiogenesis.
PG  - 30-40
LID - 10.1016/j.jvssci.2021.09.023 [doi]
AB  - OBJECTIVE: Zinc is an important essential trace metal involved in many 
      physiologic functions, and its deficiency can affect the development of multiple 
      organs, including the vasculature. However, clarity is lacking regarding the 
      effects of zinc deficiency in the regulation of angiogenesis. We investigated the 
      effects of zinc deficiency on the revascularization process through animal 
      experiments and examined the relationship between the circulating zinc levels and 
      tissue blood perfusion in patients with chronic limb-threatening ischemia (CLTI). 
      METHODS: Zinc-deficient mice and control wild-type mice had undergone surgery to 
      create unilateral hindlimb ischemia. Next, we examined the relationship between 
      the serum zinc levels and skin perfusion pressure (SPP) as an index of tissue 
      blood perfusion in patients with CLTI. A total of 51 patients with CLTI who had 
      been referred for de novo revascularization for CLTI due to arteriosclerosis 
      obliterans at our hospital from May 2012 to March 2016 were enrolled. RESULTS: 
      The zinc-deficient mice showed a significant reduction in blood flow recovery 
      rates in the ischemic limb and capillary density in the ischemic adductor muscle 
      fibers compared with the control wild-type mice. The zinc-deficient mice also 
      showed increased reactive oxygen species production after hindlimb ischemia. 
      Nicotinamide adenine dinucleotide phosphate oxidase inhibitors ameliorated the 
      zinc deficient-induced impairment of revascularization. The serum zinc levels 
      were positively associated with the SPP in the CLTI patients. Multivariate 
      regression analysis also revealed that the serum zinc levels were significantly 
      correlated with the SPP in patients with CLTI. CONCLUSIONS: Zinc deficiency 
      impaired the rate of ischemia-induced revascularization through enhanced 
      oxidative stress rates, suggesting that nutritional management for zinc 
      sufficiency could be useful in CLTI prevention and treatment.
CI  - (c) 2021 Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.
FAU - Tsuruoka, Takuya
AU  - Tsuruoka T
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University Graduate School of Medicine, Nagoya, Japan.
FAU - Kodama, Akio
AU  - Kodama A
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University Graduate School of Medicine, Nagoya, Japan.
FAU - Yamaguchi, Shukuro
AU  - Yamaguchi S
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Masutomi, Tomohiro
AU  - Masutomi T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Koyama, Akio
AU  - Koyama A
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University Graduate School of Medicine, Nagoya, Japan.
FAU - Murohara, Toyoaki
AU  - Murohara T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Komori, Kimihiro
AU  - Komori K
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University Graduate School of Medicine, Nagoya, Japan.
FAU - Shibata, Rei
AU  - Shibata R
AD  - Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate 
      School of Medicine, Nagoya, Japan.
LA  - eng
PT  - Journal Article
DEP - 20211208
PL  - United States
TA  - JVS Vasc Sci
JT  - JVS-vascular science
JID - 101767073
PMC - PMC8792263
OTO - NOTNLM
OT  - Angiogenesis
OT  - Ischemia
OT  - Zinc
EDAT- 2022/02/08 06:00
MHDA- 2022/02/08 06:01
PMCR- 2021/12/08
CRDT- 2022/02/07 05:38
PHST- 2021/04/26 00:00 [received]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2022/02/07 05:38 [entrez]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/02/08 06:01 [medline]
PHST- 2021/12/08 00:00 [pmc-release]
AID - S2666-3503(21)00046-8 [pii]
AID - 10.1016/j.jvssci.2021.09.023 [doi]
PST - epublish
SO  - JVS Vasc Sci. 2021 Dec 8;3:30-40. doi: 10.1016/j.jvssci.2021.09.023. eCollection 
      2022.