PMID- 35129442
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20220303
IS  - 1950-6112 (Electronic)
IS  - 0003-3898 (Linking)
VI  - 80
IP  - 1
DP  - 2022 Feb 1
TI  - Hyperhomocysteinemia and cardiovascular diseases.
PG  - 7-14
LID - 10.1684/abc.2021.1694 [doi]
AB  - Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired 
      through the diet, but rather synthesized as an intermediate metabolite in the 
      methionine cycle. Hcy is present in plasma, with normal levels between 5 and 
      15 mumol/L, a slightly elevated level between 15 to 30 mumol/L, moderate from 30 to 
      100 mumol/L and a value > 100 mumol/L classified as severe hyperhomocysteinemia 
      (HHcy). HHcy has been associated with inflammation and atherosclerosis and is 
      considered an independent risk factor for cardiovascular diseases (CVD). Here, we 
      review the main evidence showing the association and the possible involvement of 
      HHcy in the most common CVD.
FAU - Guieu, Regis
AU  - Guieu R
AD  - C2VN (AMU - Inserm1263 - Inrae 1260), Aix-Marseille Universite - Campus Sante 
      Timone - Faculte de Pharmacie, Marseille, France, Laboratory of Biochemistry, 
      Hopital de La Timone, Marseille, France.
FAU - Ruf, Jean
AU  - Ruf J
AD  - C2VN (AMU - Inserm1263 - Inrae 1260), Aix-Marseille Universite - Campus Sante 
      Timone - Faculte de Pharmacie, Marseille, France.
FAU - Mottola, Giovanna
AU  - Mottola G
AD  - C2VN (AMU - Inserm1263 - Inrae 1260), Aix-Marseille Universite - Campus Sante 
      Timone - Faculte de Pharmacie, Marseille, France, Laboratory of Biochemistry, 
      Hopital de La Timone, Marseille, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Ann Biol Clin (Paris)
JT  - Annales de biologie clinique
JID - 2984690R
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - *Cardiovascular Diseases/diagnosis/epidemiology/etiology
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/diagnosis
MH  - Inflammation
MH  - Methionine
MH  - Risk Factors
OTO - NOTNLM
OT  - cardiovascular
OT  - homocysteine
OT  - hyperhomocysteinemia
EDAT- 2022/02/08 06:00
MHDA- 2022/03/04 06:00
CRDT- 2022/02/07 12:13
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2022/02/07 12:13 [entrez]
AID - abc.2021.1694 [pii]
AID - 10.1684/abc.2021.1694 [doi]
PST - ppublish
SO  - Ann Biol Clin (Paris). 2022 Feb 1;80(1):7-14. doi: 10.1684/abc.2021.1694.