PMID- 35129872
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220419
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 36
IP  - 4
DP  - 2022 Apr
TI  - The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis 
      alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
PG  - 1692-1707
LID - 10.1002/ptr.7403 [doi]
AB  - Rhamnazin (RN) is a flavonol isolated from the calyxes and fruits of Physalis 
      alkekengi L. var. franchetii (Mast.) Makino, which has been used for treating 
      pulmonary diseases in traditional Chinese medicine. The nuclear factor erythroid 
      2-related factor 2 (Nrf2) is a therapeutic target for pulmonary diseases. In the 
      present study, the underlying mechanism and pharmacological effect of RN against 
      pulmonary disorders are investigated. Human lung epithelial Beas-2B cell and RAW 
      264.7 murine macrophage-based cell models, and a cigarette smoke (CS)-induced 
      pulmonary impairment mice model are adopted for investigation in vitro and in 
      vivo. RN is identified to be an Nrf2 activator, which promotes Nrf2 dissociation 
      from Keap1 via reacting with the Cys151 cysteine residue of Keap1, and suppresses 
      Nrf2 ubiquitination. In addition, RN is able to attenuate toxicant-stimulated 
      oxidative stress and inflammatory response in vitro. Importantly, RN 
      significantly relieves CS-induced oxidative insult and inflammation, and 
      RN-induced inhibition of inflammation is related to inhibition of nuclear 
      transcription factor-kappaB (NF-kappaB) and induction of cell autophagy. In conclusion, 
      our data indicate that RN is an activator of the Nrf2 pathway and evidently 
      alleviates pulmonary disorders via restricting NF-kappaB activation and promoting 
      autophagy. RN is a promising candidate for the therapy of pulmonary disorders.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Wu, Xue-Yi
AU  - Wu XY
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Wang, Tian
AU  - Wang T
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Hu, Hui-Xin
AU  - Hu HX
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Zhang, Kan
AU  - Zhang K
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Zhao, Bao-Bing
AU  - Zhao BB
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Lou, Hong-Xiang
AU  - Lou HX
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Wang, Xiao-Ning
AU  - Wang XN
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
FAU - Shen, Tao
AU  - Shen T
AUID- ORCID: 0000-0002-5474-2646
AD  - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong 
      University, Jinan, People's Republic of China.
LA  - eng
GR  - 2020QNQT007/Multidisciplinary Research and Innovation Program of Shandong 
      University/
GR  - 81874341/National Natural Sciences Foundation of China/
GR  - 81673558/National Natural Sciences Foundation of China/
GR  - Qilu Young Scholars Program of Shandong University/
GR  - 2019-0994/The fourth national survey on Chinese material medica resources/
PT  - Journal Article
DEP - 20220207
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Flavonoids)
RN  - 0 (Flavonols)
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - 276CK9GP9Y (rhamnazin)
RN  - ZTG9LSS5QH (3-hydroxyflavone)
SB  - IM
MH  - Animals
MH  - Flavonoids
MH  - Flavonols
MH  - Inflammation
MH  - Kelch-Like ECH-Associated Protein 1/metabolism
MH  - *Lung Diseases
MH  - Mice
MH  - NF-E2-Related Factor 2/metabolism
MH  - NF-kappa B/metabolism
MH  - Oxidative Stress
MH  - *Physalis/chemistry/metabolism
OTO - NOTNLM
OT  - NF-kappaB
OT  - Nrf2
OT  - autophagy
OT  - pulmonary disorders
OT  - rhamnazin
EDAT- 2022/02/08 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/02/07 12:17
PHST- 2022/01/06 00:00 [revised]
PHST- 2021/03/20 00:00 [received]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/02/08 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/02/07 12:17 [entrez]
AID - 10.1002/ptr.7403 [doi]
PST - ppublish
SO  - Phytother Res. 2022 Apr;36(4):1692-1707. doi: 10.1002/ptr.7403. Epub 2022 Feb 7.